Open Trial of Cyclosporine in Patients with Severe Active Crohn's Disease Refractory to Conventional Therapy

Fifteen patients with severe active Crohn's disease, refractory to conventional therapy, were given a 16 week course of cyclosporine ar an initial oral daily dose of 10 mg/kg, adjusted to maintain cyclosporine scrum trough levels between 100 and 200 ng/ml. Five patients withdrew early because o...

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Main Authors: Kevork M. Peltekian, C. Noel Williams, Allan S. MacDonald, Peter D. Roy, Elizabeth Czolpinska
Format: Article
Language:English
Published: Wiley 1988-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/1988/970381
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author Kevork M. Peltekian
C. Noel Williams
Allan S. MacDonald
Peter D. Roy
Elizabeth Czolpinska
author_facet Kevork M. Peltekian
C. Noel Williams
Allan S. MacDonald
Peter D. Roy
Elizabeth Czolpinska
author_sort Kevork M. Peltekian
collection DOAJ
description Fifteen patients with severe active Crohn's disease, refractory to conventional therapy, were given a 16 week course of cyclosporine ar an initial oral daily dose of 10 mg/kg, adjusted to maintain cyclosporine scrum trough levels between 100 and 200 ng/ml. Five patients withdrew early because of side effects, poor absorption or noncompliance. T he remaining 10 patients all improved within four weeks as measured by three different clinical indices: Crohn's Disease Activity Index, Simple Index of Crohn's Disease Activity and Mean Score of Therapeutic Goals (MSTG). Seven patients maintained this initial improvement and prednisone was either reduced or discontinued. Four of these seven patients relapsed with in four weeks of stopping cyclosporine, and three remain in remission after 75 ± 2 weeks. Side effects were minor and easily reversible. When the various clinical and laboratory indices were compared, MSTG was found to be the most useful index for the assessment of therapy. Cyclosporine appears to be a safe and effective therapy in patients with severe active Crohn's disease refractory to conventional therapy.
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series Canadian Journal of Gastroenterology
spelling doaj-art-3dd173310dec453da85aa1e03a51a1bd2025-02-03T01:24:29ZengWileyCanadian Journal of Gastroenterology0835-79001988-01-012151110.1155/1988/970381Open Trial of Cyclosporine in Patients with Severe Active Crohn's Disease Refractory to Conventional TherapyKevork M. Peltekian0C. Noel Williams1Allan S. MacDonald2Peter D. Roy3Elizabeth Czolpinska4Departments of Medicine and Surgery, Faculty of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, CanadaDepartments of Medicine and Surgery, Faculty of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, CanadaDepartments of Medicine and Surgery, Faculty of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, CanadaDepartments of Medicine and Surgery, Faculty of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, CanadaDepartments of Medicine and Surgery, Faculty of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, CanadaFifteen patients with severe active Crohn's disease, refractory to conventional therapy, were given a 16 week course of cyclosporine ar an initial oral daily dose of 10 mg/kg, adjusted to maintain cyclosporine scrum trough levels between 100 and 200 ng/ml. Five patients withdrew early because of side effects, poor absorption or noncompliance. T he remaining 10 patients all improved within four weeks as measured by three different clinical indices: Crohn's Disease Activity Index, Simple Index of Crohn's Disease Activity and Mean Score of Therapeutic Goals (MSTG). Seven patients maintained this initial improvement and prednisone was either reduced or discontinued. Four of these seven patients relapsed with in four weeks of stopping cyclosporine, and three remain in remission after 75 ± 2 weeks. Side effects were minor and easily reversible. When the various clinical and laboratory indices were compared, MSTG was found to be the most useful index for the assessment of therapy. Cyclosporine appears to be a safe and effective therapy in patients with severe active Crohn's disease refractory to conventional therapy.http://dx.doi.org/10.1155/1988/970381
spellingShingle Kevork M. Peltekian
C. Noel Williams
Allan S. MacDonald
Peter D. Roy
Elizabeth Czolpinska
Open Trial of Cyclosporine in Patients with Severe Active Crohn's Disease Refractory to Conventional Therapy
Canadian Journal of Gastroenterology
title Open Trial of Cyclosporine in Patients with Severe Active Crohn's Disease Refractory to Conventional Therapy
title_full Open Trial of Cyclosporine in Patients with Severe Active Crohn's Disease Refractory to Conventional Therapy
title_fullStr Open Trial of Cyclosporine in Patients with Severe Active Crohn's Disease Refractory to Conventional Therapy
title_full_unstemmed Open Trial of Cyclosporine in Patients with Severe Active Crohn's Disease Refractory to Conventional Therapy
title_short Open Trial of Cyclosporine in Patients with Severe Active Crohn's Disease Refractory to Conventional Therapy
title_sort open trial of cyclosporine in patients with severe active crohn s disease refractory to conventional therapy
url http://dx.doi.org/10.1155/1988/970381
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