The Neuroprotective Effect of Cornus mas on Brain Tissue of Wistar Rats
Cornelian cherry (Cornus mas) is a valuable source of phenolic antioxidants. Flavonoid derivatives as nonenzymatic antioxidants are important in the pathophysiology of many diseases including neurological disorders (e.g., Alzheimer’s disease) or heart disease. In this study, we examined the effect o...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/847368 |
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| author | Renata Francik Jadwiga Kryczyk Mirosław Krośniak Mehmet Berköz Ilona Sanocka Sławomir Francik |
| author_facet | Renata Francik Jadwiga Kryczyk Mirosław Krośniak Mehmet Berköz Ilona Sanocka Sławomir Francik |
| author_sort | Renata Francik |
| collection | DOAJ |
| description | Cornelian cherry (Cornus mas) is a valuable source of phenolic antioxidants. Flavonoid derivatives as nonenzymatic antioxidants are important in the pathophysiology of many diseases including neurological disorders (e.g., Alzheimer’s disease) or heart disease. In this study, we examined the effect of an addition of freeze-dried fruit of cornelian cherry on three types of diets: control diet, fructose diet, and diet enriched in fats (high-fat diet). This effect was studied by determining the following antioxidant parameters in both brain tissue and plasma in rats: catalase, ferric reducing ability of plasma, paraoxonase, protein carbonyl groups, and free thiol groups. Results indicate that both fructose diet and high-fat diet affect the antioxidant capacity of the organism. Furthermore, an addition of cornelian cherry resulted in increased activity of catalase in brain tissue, while in plasma it caused the opposite effect. In turn, with regard to paraoxonase activity in both brain tissue and plasma, it had a stimulating effect. Adding cornelian cherry to the tested diets increased the activity of PON in both tested tissues. Moreover, protective effect of fruits of this plant was observed in the process of oxidation of proteins by decreasing levels of protein carbonyl groups and thiol groups in brain tissue as well as in plasma. |
| format | Article |
| id | doaj-art-3dc243c8ddb340deb4d5a8680ee1b85b |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-3dc243c8ddb340deb4d5a8680ee1b85b2025-02-03T01:28:51ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/847368847368The Neuroprotective Effect of Cornus mas on Brain Tissue of Wistar RatsRenata Francik0Jadwiga Kryczyk1Mirosław Krośniak2Mehmet Berköz3Ilona Sanocka4Sławomir Francik5Department of Bioorganic Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, PolandDepartment of Food Chemistry and Nutrition, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, PolandDepartment of Food Chemistry and Nutrition, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, PolandDepartment of Pharmaceutical Biotechnology, Faculty of Pharmacy, Yuzuncu Yıl University, Zeve Campus, 65080 Van, TurkeyDepartment of Bioorganic Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, PolandDepartment of Mechanical Engineering and Agrophysics, Faculty of Production Engineering and Energetics, University of Agriculture in Krakow, 116 B Balicka Street, 30-149 Krakow, PolandCornelian cherry (Cornus mas) is a valuable source of phenolic antioxidants. Flavonoid derivatives as nonenzymatic antioxidants are important in the pathophysiology of many diseases including neurological disorders (e.g., Alzheimer’s disease) or heart disease. In this study, we examined the effect of an addition of freeze-dried fruit of cornelian cherry on three types of diets: control diet, fructose diet, and diet enriched in fats (high-fat diet). This effect was studied by determining the following antioxidant parameters in both brain tissue and plasma in rats: catalase, ferric reducing ability of plasma, paraoxonase, protein carbonyl groups, and free thiol groups. Results indicate that both fructose diet and high-fat diet affect the antioxidant capacity of the organism. Furthermore, an addition of cornelian cherry resulted in increased activity of catalase in brain tissue, while in plasma it caused the opposite effect. In turn, with regard to paraoxonase activity in both brain tissue and plasma, it had a stimulating effect. Adding cornelian cherry to the tested diets increased the activity of PON in both tested tissues. Moreover, protective effect of fruits of this plant was observed in the process of oxidation of proteins by decreasing levels of protein carbonyl groups and thiol groups in brain tissue as well as in plasma.http://dx.doi.org/10.1155/2014/847368 |
| spellingShingle | Renata Francik Jadwiga Kryczyk Mirosław Krośniak Mehmet Berköz Ilona Sanocka Sławomir Francik The Neuroprotective Effect of Cornus mas on Brain Tissue of Wistar Rats The Scientific World Journal |
| title | The Neuroprotective Effect of Cornus mas on Brain Tissue of Wistar Rats |
| title_full | The Neuroprotective Effect of Cornus mas on Brain Tissue of Wistar Rats |
| title_fullStr | The Neuroprotective Effect of Cornus mas on Brain Tissue of Wistar Rats |
| title_full_unstemmed | The Neuroprotective Effect of Cornus mas on Brain Tissue of Wistar Rats |
| title_short | The Neuroprotective Effect of Cornus mas on Brain Tissue of Wistar Rats |
| title_sort | neuroprotective effect of cornus mas on brain tissue of wistar rats |
| url | http://dx.doi.org/10.1155/2014/847368 |
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