Validation of the ABC Method for Gastric Cancer Risk Stratification Across Helicobacter pylori Infections With Diverse CagA Status and Subtypes in Brazil

Validation of the ABC Method for Gastric Cancer Risk Stratification Across Helicobacter pylori Infections With Diverse CagA Status and Subtypes in Brazil

ABSTRACT Background Gastric cancer survival rates vary across countries due to differences in access to early diagnostic testing and healthcare quality. Endoscopy, though accurate, is not feasible for mass screening. The ABC method, which combines serum Helicobacter pylori (Hp) antibody and pepsinog...

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Main Authors: Luis Masuo Maruta, Asuka Furukawa, Heinrich Bender Kohnert Seidler, Aloisio Felipe‐Silva, Keisuke Uchida, Daisuke Kobayashi, Kurara Yamamoto, Junko Minami, Masaki Sekine, Minako Takagi, Renato Takayuki Hassegawa, Eduardo Koji Marchi Ogawa, Rodrigo Barbosa Villaça, Tecio deAraujo Couto, Jorge Alberto Capra Biasuz, Edmar Tafner, Ana Luiza Werneck‐Silva, Simone Perez Pilli, José Guilherme Nogueira daSilva, Leonard Medeiros daSilva, Ricardo Ambrosio Fock, Chinatsu Ogura, Yumi Mizuguchi, Keiko Miura, Kouhei Yamamoto, Yoshinobu Eishi, Kenichi Ohashi
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Cancer Medicine
Subjects:
ABC method
CagA subtyping
gastric cancer risk stratification
Helicobacter pylori CagA diversity
immunohistochemistry
intestinal metaplasia
Online Access:https://doi.org/10.1002/cam4.71016
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