Beneficial microbiome and diet interplay in early-onset colorectal cancer
Abstract Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer-related deaths worldwide. Although the risk of developing CRC increases with age, approximately 10% of newly diagnosed cases occur in individuals under the age of 50. Significant chang...
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| Format: | Article |
| Language: | English |
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Springer Nature
2024-12-01
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| Series: | EMBO Molecular Medicine |
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| Online Access: | https://doi.org/10.1038/s44321-024-00177-0 |
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| author | Zhengyuan Zhou Linda Kleis Ana Depetris-Chauvin Stefanie Jaskulski Victoria Damerell Karin B Michels Biljana Gigic Ute Nöthlings Gianni Panagiotou |
| author_facet | Zhengyuan Zhou Linda Kleis Ana Depetris-Chauvin Stefanie Jaskulski Victoria Damerell Karin B Michels Biljana Gigic Ute Nöthlings Gianni Panagiotou |
| author_sort | Zhengyuan Zhou |
| collection | DOAJ |
| description | Abstract Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer-related deaths worldwide. Although the risk of developing CRC increases with age, approximately 10% of newly diagnosed cases occur in individuals under the age of 50. Significant changes in dietary habits in young adults since industrialization create a favorable microenvironment for colorectal carcinogenesis. We aim here to shed light on the complex interplay between diet and gut microbiome in the pathogenesis and prevention of early-onset CRC (EO-CRC). We provide an overview of dietary risk factors associated with EO-CRC and contrast them with the general trends for CRC. We delve into gut bacteria, fungi, and phages with potential benefits against CRC and discuss the underlying molecular mechanisms. Furthermore, based on recent findings from human studies, we offer insights into how dietary modifications could potentially enhance gut microbiome composition to mitigate CRC risk. All together, we outline the current research landscape in this area and propose directions for future investigations that could pave the way for novel preventive and therapeutic strategies. |
| format | Article |
| id | doaj-art-3dc007d5b31142f98d37d2051cc0f1a0 |
| institution | Kabale University |
| issn | 1757-4684 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-3dc007d5b31142f98d37d2051cc0f1a02025-01-19T12:34:38ZengSpringer NatureEMBO Molecular Medicine1757-46842024-12-0117193010.1038/s44321-024-00177-0Beneficial microbiome and diet interplay in early-onset colorectal cancerZhengyuan Zhou0Linda Kleis1Ana Depetris-Chauvin2Stefanie Jaskulski3Victoria Damerell4Karin B Michels5Biljana Gigic6Ute Nöthlings7Gianni Panagiotou8Department of Microbiome Dynamics, Leibniz Institute for Natural Product Research and Infection Biology (Leibniz-HKI)Institute of Nutritional and Food Sciences-Nutritional Epidemiology, University of BonnDepartment of Microbiome Dynamics, Leibniz Institute for Natural Product Research and Infection Biology (Leibniz-HKI)Institute for Prevention and Cancer Epidemiology, Faculty of Medicine and Medical Center, University of FreiburgDepartment of General, Visceral and Transplantation Surgery, Heidelberg University HospitalInstitute for Prevention and Cancer Epidemiology, Faculty of Medicine and Medical Center, University of FreiburgDepartment of General, Visceral and Transplantation Surgery, Heidelberg University HospitalInstitute of Nutritional and Food Sciences-Nutritional Epidemiology, University of BonnDepartment of Microbiome Dynamics, Leibniz Institute for Natural Product Research and Infection Biology (Leibniz-HKI)Abstract Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer-related deaths worldwide. Although the risk of developing CRC increases with age, approximately 10% of newly diagnosed cases occur in individuals under the age of 50. Significant changes in dietary habits in young adults since industrialization create a favorable microenvironment for colorectal carcinogenesis. We aim here to shed light on the complex interplay between diet and gut microbiome in the pathogenesis and prevention of early-onset CRC (EO-CRC). We provide an overview of dietary risk factors associated with EO-CRC and contrast them with the general trends for CRC. We delve into gut bacteria, fungi, and phages with potential benefits against CRC and discuss the underlying molecular mechanisms. Furthermore, based on recent findings from human studies, we offer insights into how dietary modifications could potentially enhance gut microbiome composition to mitigate CRC risk. All together, we outline the current research landscape in this area and propose directions for future investigations that could pave the way for novel preventive and therapeutic strategies.https://doi.org/10.1038/s44321-024-00177-0DietEarly-onset Colorectal CancerGut MicrobiomePreventionTherapy |
| spellingShingle | Zhengyuan Zhou Linda Kleis Ana Depetris-Chauvin Stefanie Jaskulski Victoria Damerell Karin B Michels Biljana Gigic Ute Nöthlings Gianni Panagiotou Beneficial microbiome and diet interplay in early-onset colorectal cancer EMBO Molecular Medicine Diet Early-onset Colorectal Cancer Gut Microbiome Prevention Therapy |
| title | Beneficial microbiome and diet interplay in early-onset colorectal cancer |
| title_full | Beneficial microbiome and diet interplay in early-onset colorectal cancer |
| title_fullStr | Beneficial microbiome and diet interplay in early-onset colorectal cancer |
| title_full_unstemmed | Beneficial microbiome and diet interplay in early-onset colorectal cancer |
| title_short | Beneficial microbiome and diet interplay in early-onset colorectal cancer |
| title_sort | beneficial microbiome and diet interplay in early onset colorectal cancer |
| topic | Diet Early-onset Colorectal Cancer Gut Microbiome Prevention Therapy |
| url | https://doi.org/10.1038/s44321-024-00177-0 |
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