Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease
The Grb-2 associated binder (Gab) family of scaffolding/adaptor/docking proteins is a group of three molecules with significant roles in cytokine receptor signaling. Gabs possess structural motifs for phosphorylation-dependent receptor recruitment, Grb2 binding, and activation of downstream signalin...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2012/380635 |
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| _version_ | 1832547072223477760 |
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| author | Sheetal Verma Tamisha Vaughan Kevin D. Bunting |
| author_facet | Sheetal Verma Tamisha Vaughan Kevin D. Bunting |
| author_sort | Sheetal Verma |
| collection | DOAJ |
| description | The Grb-2 associated binder (Gab) family of scaffolding/adaptor/docking proteins is a group of three molecules with significant roles in cytokine receptor signaling. Gabs possess structural motifs for phosphorylation-dependent receptor recruitment, Grb2 binding, and activation of downstream signaling pathways through p85 and SHP-2. In addition, Gabs participate in hematopoiesis and regulation of immune response which can be aberrantly activated in cancer and inflammation. The multifunctionality of Gab adapters might suggest that they would be too difficult to consider as candidates for “targeted” therapy. However, the one drug/one target approach is giving way to the concept of one drug/multiple target approach since few cancers are addicted to a single signaling molecule for survival and combination drug therapies can be problematic. In this paper, we cover recent findings on Gab multi-functionality, binding partners, and their role in hematological malignancy and examine the concept of Gab-targeted therapy. |
| format | Article |
| id | doaj-art-3dbadba4a6444f9ebb9c36efa8930922 |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-3dbadba4a6444f9ebb9c36efa89309222025-02-03T06:46:03ZengWileyAdvances in Hematology1687-91041687-91122012-01-01201210.1155/2012/380635380635Gab Adapter Proteins as Therapeutic Targets for Hematologic DiseaseSheetal Verma0Tamisha Vaughan1Kevin D. Bunting2Aflac Cancer Center of Children's Healthcare of Atlanta, Department of Pediatrics, Emory University, Atlanta, GA 30322, USAAflac Cancer Center of Children's Healthcare of Atlanta, Department of Pediatrics, Emory University, Atlanta, GA 30322, USAAflac Cancer Center of Children's Healthcare of Atlanta, Department of Pediatrics, Emory University, Atlanta, GA 30322, USAThe Grb-2 associated binder (Gab) family of scaffolding/adaptor/docking proteins is a group of three molecules with significant roles in cytokine receptor signaling. Gabs possess structural motifs for phosphorylation-dependent receptor recruitment, Grb2 binding, and activation of downstream signaling pathways through p85 and SHP-2. In addition, Gabs participate in hematopoiesis and regulation of immune response which can be aberrantly activated in cancer and inflammation. The multifunctionality of Gab adapters might suggest that they would be too difficult to consider as candidates for “targeted” therapy. However, the one drug/one target approach is giving way to the concept of one drug/multiple target approach since few cancers are addicted to a single signaling molecule for survival and combination drug therapies can be problematic. In this paper, we cover recent findings on Gab multi-functionality, binding partners, and their role in hematological malignancy and examine the concept of Gab-targeted therapy.http://dx.doi.org/10.1155/2012/380635 |
| spellingShingle | Sheetal Verma Tamisha Vaughan Kevin D. Bunting Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease Advances in Hematology |
| title | Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease |
| title_full | Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease |
| title_fullStr | Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease |
| title_full_unstemmed | Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease |
| title_short | Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease |
| title_sort | gab adapter proteins as therapeutic targets for hematologic disease |
| url | http://dx.doi.org/10.1155/2012/380635 |
| work_keys_str_mv | AT sheetalverma gabadapterproteinsastherapeutictargetsforhematologicdisease AT tamishavaughan gabadapterproteinsastherapeutictargetsforhematologicdisease AT kevindbunting gabadapterproteinsastherapeutictargetsforhematologicdisease |