Steroid receptors in meningiomas
Cytosolic estrogen (ER), progesterone (PR), androgen (AR) and glucocorticoid receptors (GR) were evaluated in 10 meningiomas using a dextran charcoal coated method. We consider as positive specific receptor values >10fMol/mg protein. In this study 20% of the meningiomas contained very low titers...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações
1985-12-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1985000400005&lng=en&tlng=en |
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| author | J. P. P. Plese V. R. Martins M. T. P. Lopes M. M. Brentani |
| author_facet | J. P. P. Plese V. R. Martins M. T. P. Lopes M. M. Brentani |
| author_sort | J. P. P. Plese |
| collection | DOAJ |
| description | Cytosolic estrogen (ER), progesterone (PR), androgen (AR) and glucocorticoid receptors (GR) were evaluated in 10 meningiomas using a dextran charcoal coated method. We consider as positive specific receptor values >10fMol/mg protein. In this study 20% of the meningiomas contained very low titers of specific ER. PR was detectable in 90% of the tumors, at high levels. The mean PR content of PR+ tumors was 60±38fMol/mg prot. GR and AR were present in moderate levels, in 70% of the tumors. Competition studies demonstrated steroid specificity for these hormone-binding proteins. Female patients have a higher receptor incidence and titer. In conclusion, it can be hypothesized that the meningioma are a target tissue for steroids and that endocrine therapy may be relevant to unoperable and/or reccurent tumors. |
| format | Article |
| id | doaj-art-3dbaab27b7b9451f8c7c7df9ca6e8277 |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publishDate | 1985-12-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-3dbaab27b7b9451f8c7c7df9ca6e82772025-08-20T01:56:44ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42271985-12-0143436537110.1590/S0004-282X1985000400005S0004-282X1985000400005Steroid receptors in meningiomasJ. P. P. Plese0V. R. Martins1M. T. P. Lopes2M. M. Brentani3Universidade de São PauloUniversidade de São PauloUniversidade de São PauloUniversidade de São PauloCytosolic estrogen (ER), progesterone (PR), androgen (AR) and glucocorticoid receptors (GR) were evaluated in 10 meningiomas using a dextran charcoal coated method. We consider as positive specific receptor values >10fMol/mg protein. In this study 20% of the meningiomas contained very low titers of specific ER. PR was detectable in 90% of the tumors, at high levels. The mean PR content of PR+ tumors was 60±38fMol/mg prot. GR and AR were present in moderate levels, in 70% of the tumors. Competition studies demonstrated steroid specificity for these hormone-binding proteins. Female patients have a higher receptor incidence and titer. In conclusion, it can be hypothesized that the meningioma are a target tissue for steroids and that endocrine therapy may be relevant to unoperable and/or reccurent tumors.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1985000400005&lng=en&tlng=en |
| spellingShingle | J. P. P. Plese V. R. Martins M. T. P. Lopes M. M. Brentani Steroid receptors in meningiomas Arquivos de Neuro-Psiquiatria |
| title | Steroid receptors in meningiomas |
| title_full | Steroid receptors in meningiomas |
| title_fullStr | Steroid receptors in meningiomas |
| title_full_unstemmed | Steroid receptors in meningiomas |
| title_short | Steroid receptors in meningiomas |
| title_sort | steroid receptors in meningiomas |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1985000400005&lng=en&tlng=en |
| work_keys_str_mv | AT jppplese steroidreceptorsinmeningiomas AT vrmartins steroidreceptorsinmeningiomas AT mtplopes steroidreceptorsinmeningiomas AT mmbrentani steroidreceptorsinmeningiomas |