Clenbuterol and metformin ameliorate cachexia parameters, but only clenbuterol reduces tumor growth via lipid peroxidation in Walker 256 tumor-bearing rats

Clenbuterol and metformin ameliorate cachexia parameters, but only clenbuterol reduces tumor growth via lipid peroxidation in Walker 256 tumor-bearing rats

Cancer is the second leading cause of death worldwide. Cancer cachexia is a multifactorial catabolic syndrome responsible for almost one third of cancer-related deaths. Drug repurposing has been used in oncological research and drugs like clenbuterol and metformin seem to be reasonable candidates in...

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Bibliographic Details
Main Authors: L.D.V. Henschel, M.E.R. de Lima, F.C. Fagundes, T. Horlem, M.F. Zazula, K. Naliwaiko, L.C. Fernandes
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2025-01-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Cancer cachexia
Tumor
Clenbuterol
Metformin
Walker 256
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2025000100601&lng=en&tlng=en
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