Analysis of clinical characteristics of hemorrhagic fever with renal syndrome with acute pancreatitis: a retrospective study
Objective This research aimed to analyze the impact of hemorrhagic fever with renal syndrome (HFRS) with acute pancreatitis (AP) on the severity and prognosis of patients, screen the risk factors of HFRS with AP, and establish a nomogram model.Methods Data were collected from HFRS patients at the Fi...
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2025.2453081 |
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| author | Lihua Huang Min Xiao Xiaoling Huang Jun Wu Jiao Luo Fuxing Li Wei Gu |
| author_facet | Lihua Huang Min Xiao Xiaoling Huang Jun Wu Jiao Luo Fuxing Li Wei Gu |
| author_sort | Lihua Huang |
| collection | DOAJ |
| description | Objective This research aimed to analyze the impact of hemorrhagic fever with renal syndrome (HFRS) with acute pancreatitis (AP) on the severity and prognosis of patients, screen the risk factors of HFRS with AP, and establish a nomogram model.Methods Data were collected from HFRS patients at the First Affiliated Hospital of Dali University and Dali Prefecture People’s Hospital (2013-2023). Patients were divided into HFRS with AP (n = 34) and HFRS without AP groups (n = 356). Propensity Score Matching (PSM) and logistic regression analyzed the impact of AP on HFRS severity and short-term prognosis. LASSO-Logistic regression was used to screen risk factors and develop a nomogram model.Results After PSM, HFRS patients with AP had higher rates of Continuous Renal Replacement Therapy (CRRT) and/or mechanical ventilation use, , ICU admission, and 30-day mortalitycompared with those without AP (p < 0.05). Further analysis revealed that smoking (OR: 3.702), ferritin (OR: 1.002), white blood cell (OR), fibrinogen (OR: 0.463), and platelet (OR: 0.987) were risk factors for HFRS with AP (p < 0.05). A nomogram model was constructed based on these factors, to predict the risk of HFRS with AP, with an Area Under the Curve (AUC) of 0.90 (95% CI: 0.84–0.95). Additionally, the model calibration curve fit well according to the Hosmer-Lemeshow test (χ2=8.51, p = 0.39).Conclusion Patients with HFRS with AP exhibit higher disease severity and poorer prognosis. Smoking, elevated ferritin and white blood cell levels, decreased fibrinogen and platelet levels are more susceptible to developing AP. |
| format | Article |
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| institution | Kabale University |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-3db4b6e6a57b46098ef751b1ae15787e2025-01-20T09:49:05ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2453081Analysis of clinical characteristics of hemorrhagic fever with renal syndrome with acute pancreatitis: a retrospective studyLihua Huang0Min Xiao1Xiaoling Huang2Jun Wu3Jiao Luo4Fuxing Li5Wei Gu6Department of Infection Disease, The First Affiliated Hospital of Dali University, Dali, Yunnan, ChinaDepartment of Clinical Laboratory, Sichuan Provincial People’s Hospital East Sichuan Hospital & DaZhou First People’s Hospital, Dazhou, Sichuan, ChinaDepartment of Respiratory Medicine, Sichuan Provincial People’s Hospital East Sichuan Hospital & Dazhou First People’s Hospital, Dazhou, Sichuan, ChinaDepartment of Ophthalmology, Dali Prefecture People’s Hospital, Dali, Yunnan, ChinaDepartment of Infection Disease, The First Affiliated Hospital of Dali University, Dali, Yunnan, ChinaJiangxi Province Key Laboratory of Immunology and Inflammation, Jiangxi Provincial Clinical Research Center for Laboratory Medicine, Department of Clinical Laboratory, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Infection Disease, The First Affiliated Hospital of Dali University, Dali, Yunnan, ChinaObjective This research aimed to analyze the impact of hemorrhagic fever with renal syndrome (HFRS) with acute pancreatitis (AP) on the severity and prognosis of patients, screen the risk factors of HFRS with AP, and establish a nomogram model.Methods Data were collected from HFRS patients at the First Affiliated Hospital of Dali University and Dali Prefecture People’s Hospital (2013-2023). Patients were divided into HFRS with AP (n = 34) and HFRS without AP groups (n = 356). Propensity Score Matching (PSM) and logistic regression analyzed the impact of AP on HFRS severity and short-term prognosis. LASSO-Logistic regression was used to screen risk factors and develop a nomogram model.Results After PSM, HFRS patients with AP had higher rates of Continuous Renal Replacement Therapy (CRRT) and/or mechanical ventilation use, , ICU admission, and 30-day mortalitycompared with those without AP (p < 0.05). Further analysis revealed that smoking (OR: 3.702), ferritin (OR: 1.002), white blood cell (OR), fibrinogen (OR: 0.463), and platelet (OR: 0.987) were risk factors for HFRS with AP (p < 0.05). A nomogram model was constructed based on these factors, to predict the risk of HFRS with AP, with an Area Under the Curve (AUC) of 0.90 (95% CI: 0.84–0.95). Additionally, the model calibration curve fit well according to the Hosmer-Lemeshow test (χ2=8.51, p = 0.39).Conclusion Patients with HFRS with AP exhibit higher disease severity and poorer prognosis. Smoking, elevated ferritin and white blood cell levels, decreased fibrinogen and platelet levels are more susceptible to developing AP.https://www.tandfonline.com/doi/10.1080/07853890.2025.2453081Haemorrhagic fever with renal syndromeacute pancreatitisclinical characteristicsrisk factorsnomogram |
| spellingShingle | Lihua Huang Min Xiao Xiaoling Huang Jun Wu Jiao Luo Fuxing Li Wei Gu Analysis of clinical characteristics of hemorrhagic fever with renal syndrome with acute pancreatitis: a retrospective study Annals of Medicine Haemorrhagic fever with renal syndrome acute pancreatitis clinical characteristics risk factors nomogram |
| title | Analysis of clinical characteristics of hemorrhagic fever with renal syndrome with acute pancreatitis: a retrospective study |
| title_full | Analysis of clinical characteristics of hemorrhagic fever with renal syndrome with acute pancreatitis: a retrospective study |
| title_fullStr | Analysis of clinical characteristics of hemorrhagic fever with renal syndrome with acute pancreatitis: a retrospective study |
| title_full_unstemmed | Analysis of clinical characteristics of hemorrhagic fever with renal syndrome with acute pancreatitis: a retrospective study |
| title_short | Analysis of clinical characteristics of hemorrhagic fever with renal syndrome with acute pancreatitis: a retrospective study |
| title_sort | analysis of clinical characteristics of hemorrhagic fever with renal syndrome with acute pancreatitis a retrospective study |
| topic | Haemorrhagic fever with renal syndrome acute pancreatitis clinical characteristics risk factors nomogram |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2453081 |
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