Establishment of an infectious clone of the porcine transmissible gastroenteritis virus and a study on the location and function of accessory protein 3

Establishment of an infectious clone of the porcine transmissible gastroenteritis virus and a study on the location and function of accessory protein 3

IntroductionTransmissible gastroenteritis virus (TGEV), as the causative agent of TGE, causes huge economic losses in the pig industry worldwide.MethodsIn this study, we successfully constructed a reverse genetic system for the TGEV TH-98 strain and rescued the recombinant virus rTH-98-Δ3-COE-HA bas...

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Bibliographic Details
Main Authors: Zhenye Hao, Lifei Liu, Shuai Wang, Yanping Jiang, Jiaxuan Li, Wen Cui, Li Wang, Yijing Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
TGEV
ORF3
reverse genetics
viral replication
immunogenicity
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1609022/full
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