Differential Circulating Fungal Microbiome in Prostate Cancer Patients Compared to Healthy Control Individuals
Backgrounds. Infection and inflammation play an important role in prostate cancer (PCa) etiology and pathogenesis. However, the environmental drivers for PCa are not fully understood. Methods. In a cross-sectional study, we analyzed circulating fungal microbiome in plasma samples from age and race-m...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2022/2574964 |
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| _version_ | 1832550896123248640 |
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| author | Xu Wang Zejun Zhou David Turner Michael Lilly Tongwen Ou Wei Jiang |
| author_facet | Xu Wang Zejun Zhou David Turner Michael Lilly Tongwen Ou Wei Jiang |
| author_sort | Xu Wang |
| collection | DOAJ |
| description | Backgrounds. Infection and inflammation play an important role in prostate cancer (PCa) etiology and pathogenesis. However, the environmental drivers for PCa are not fully understood. Methods. In a cross-sectional study, we analyzed circulating fungal microbiome in plasma samples from age and race-matched healthy control men (n=34) and preoperative PCa patients (n=31). Results. The fungal community in the plasma exhibited differences between individuals with PCa and healthy controls according to the beta diversity; there was no difference in the alpha diversity. Moreover, the relative abundance of several fungi differed between the two study groups from the class to species levels. The most significant differences were Filobasidiales family, Pyronemataceae family, and Cryptococcus ater species, which were enriched in PCa patients compared to controls. The increased Bipolaris genus was associated with low prostate-specific antigen (PSA) levels, increased Sordariomycetes class was associated with severe pathological stage, and decreased Phoma herbarum species was associated with disease relapse, compared to corresponding controls. Several fungi from class to species levels were increased in the controls compared to patients. Conclusion. This is the first study to show plasma distinct fungal microbiome and its associations with PSA levels, relapse, and pathology stages in PCa patients. |
| format | Article |
| id | doaj-art-3da3d394c59942ae94a7f40fde60c2e3 |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-3da3d394c59942ae94a7f40fde60c2e32025-02-03T06:05:32ZengWileyJournal of Immunology Research2314-71562022-01-01202210.1155/2022/2574964Differential Circulating Fungal Microbiome in Prostate Cancer Patients Compared to Healthy Control IndividualsXu Wang0Zejun Zhou1David Turner2Michael Lilly3Tongwen Ou4Wei Jiang5Department of Microbiology and ImmunologyState Key Laboratory of Developmental Biology of Freshwater FishDepartment of Pathology and Laboratory MedicineDivision of Hematology and OncologyDepartment of UrologyDepartment of Microbiology and ImmunologyBackgrounds. Infection and inflammation play an important role in prostate cancer (PCa) etiology and pathogenesis. However, the environmental drivers for PCa are not fully understood. Methods. In a cross-sectional study, we analyzed circulating fungal microbiome in plasma samples from age and race-matched healthy control men (n=34) and preoperative PCa patients (n=31). Results. The fungal community in the plasma exhibited differences between individuals with PCa and healthy controls according to the beta diversity; there was no difference in the alpha diversity. Moreover, the relative abundance of several fungi differed between the two study groups from the class to species levels. The most significant differences were Filobasidiales family, Pyronemataceae family, and Cryptococcus ater species, which were enriched in PCa patients compared to controls. The increased Bipolaris genus was associated with low prostate-specific antigen (PSA) levels, increased Sordariomycetes class was associated with severe pathological stage, and decreased Phoma herbarum species was associated with disease relapse, compared to corresponding controls. Several fungi from class to species levels were increased in the controls compared to patients. Conclusion. This is the first study to show plasma distinct fungal microbiome and its associations with PSA levels, relapse, and pathology stages in PCa patients.http://dx.doi.org/10.1155/2022/2574964 |
| spellingShingle | Xu Wang Zejun Zhou David Turner Michael Lilly Tongwen Ou Wei Jiang Differential Circulating Fungal Microbiome in Prostate Cancer Patients Compared to Healthy Control Individuals Journal of Immunology Research |
| title | Differential Circulating Fungal Microbiome in Prostate Cancer Patients Compared to Healthy Control Individuals |
| title_full | Differential Circulating Fungal Microbiome in Prostate Cancer Patients Compared to Healthy Control Individuals |
| title_fullStr | Differential Circulating Fungal Microbiome in Prostate Cancer Patients Compared to Healthy Control Individuals |
| title_full_unstemmed | Differential Circulating Fungal Microbiome in Prostate Cancer Patients Compared to Healthy Control Individuals |
| title_short | Differential Circulating Fungal Microbiome in Prostate Cancer Patients Compared to Healthy Control Individuals |
| title_sort | differential circulating fungal microbiome in prostate cancer patients compared to healthy control individuals |
| url | http://dx.doi.org/10.1155/2022/2574964 |
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