Development and validation of a novel classification for characterizing degenerative spondylolisthesis of lumbar spine
Abstract To performed classification based on global alignment and segmental balance, to better characterize single-segment Meyerding Grade I degenerative spondylolisthesis of lumbar spine (DSLS). A multicenter retrospective cohort study was performed, where 278 and 92 DSLS composed derivation and v...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-06298-x |
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| author | Yuqiaoi Li Chong Zhao Yonghao Wu Shuaiqi Zhu Haiying Liu Shuai Xu |
| author_facet | Yuqiaoi Li Chong Zhao Yonghao Wu Shuaiqi Zhu Haiying Liu Shuai Xu |
| author_sort | Yuqiaoi Li |
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| description | Abstract To performed classification based on global alignment and segmental balance, to better characterize single-segment Meyerding Grade I degenerative spondylolisthesis of lumbar spine (DSLS). A multicenter retrospective cohort study was performed, where 278 and 92 DSLS composed derivation and validation cohorts. Radiographical parameters contained lumbar lordosis (LL), pelvic incidence (PI), pelvic tilt (PT), sacral slope (SS) and sagittal vertical axis (SVA) and inflected and apical vertebrae. The quality-of life scales contained visual analog scales of low back pain (VAS-LBP) and leg pain (VAS-LP) and Oswestry Disability Index (ODI). The classification system was based on global alignment type and PI-LL: Type 1 and 2 with PI < 50°, while inflection < L2 in Type 1, Type 3 and 4 with PI ≥ 50°, while SS < 45° in Type 3; Subtype 2 A and 3 A with ideal PI-LL while 2B and 3B with unideal PI-LL. In derivation cohort, all DSLS acquired reduction and quality-of-life scales improved. At baseline, ODI and VAS-LBP was the highest in type 4, higher than type 3 and 1 (P = 0.030 and P = 0.041) but not for VAS-LP. In PI-LL subtype, ODI was worse in PI-LL mismatch subgroup in type 2 and 3 and VAS-LBP was worse in PI-LL mismatch subgroup in type 3 compared to match subgroup. All quality-of life scales were comparable among types. In validation cohort, there was 2 A-2B and 3 A-3B difference on ODI but comparable after surgery. The DSLS classification based on global shape (type 1–4) and PI-LL (A and B) was developed, where type 4 was linked to poor quality-of-life. This process broaden comprehensive analysis for DSLS. |
| format | Article |
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| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-3da11eb99f6b4f0fbde1e2986d77480a2025-08-20T03:03:37ZengNature PortfolioScientific Reports2045-23222025-07-0115111010.1038/s41598-025-06298-xDevelopment and validation of a novel classification for characterizing degenerative spondylolisthesis of lumbar spineYuqiaoi Li0Chong Zhao1Yonghao Wu2Shuaiqi Zhu3Haiying Liu4Shuai Xu5Department of Spinal Surgery, Peking University People’s Hospital, Peking UniversityDepartment of Spinal Surgery, Peking University People’s Hospital, Peking UniversityDepartment of Spinal Surgery, Peking University People’s Hospital, Peking UniversityDepartment of Spinal Surgery, Peking University People’s Hospital, Peking UniversityDepartment of Spinal Surgery, Peking University People’s Hospital, Peking UniversityDepartment of Spinal Surgery, Peking University People’s Hospital, Peking UniversityAbstract To performed classification based on global alignment and segmental balance, to better characterize single-segment Meyerding Grade I degenerative spondylolisthesis of lumbar spine (DSLS). A multicenter retrospective cohort study was performed, where 278 and 92 DSLS composed derivation and validation cohorts. Radiographical parameters contained lumbar lordosis (LL), pelvic incidence (PI), pelvic tilt (PT), sacral slope (SS) and sagittal vertical axis (SVA) and inflected and apical vertebrae. The quality-of life scales contained visual analog scales of low back pain (VAS-LBP) and leg pain (VAS-LP) and Oswestry Disability Index (ODI). The classification system was based on global alignment type and PI-LL: Type 1 and 2 with PI < 50°, while inflection < L2 in Type 1, Type 3 and 4 with PI ≥ 50°, while SS < 45° in Type 3; Subtype 2 A and 3 A with ideal PI-LL while 2B and 3B with unideal PI-LL. In derivation cohort, all DSLS acquired reduction and quality-of-life scales improved. At baseline, ODI and VAS-LBP was the highest in type 4, higher than type 3 and 1 (P = 0.030 and P = 0.041) but not for VAS-LP. In PI-LL subtype, ODI was worse in PI-LL mismatch subgroup in type 2 and 3 and VAS-LBP was worse in PI-LL mismatch subgroup in type 3 compared to match subgroup. All quality-of life scales were comparable among types. In validation cohort, there was 2 A-2B and 3 A-3B difference on ODI but comparable after surgery. The DSLS classification based on global shape (type 1–4) and PI-LL (A and B) was developed, where type 4 was linked to poor quality-of-life. This process broaden comprehensive analysis for DSLS.https://doi.org/10.1038/s41598-025-06298-xDegenerative spondylolisthesis of lumbar spineGlobal alignmentBalanceClassification |
| spellingShingle | Yuqiaoi Li Chong Zhao Yonghao Wu Shuaiqi Zhu Haiying Liu Shuai Xu Development and validation of a novel classification for characterizing degenerative spondylolisthesis of lumbar spine Scientific Reports Degenerative spondylolisthesis of lumbar spine Global alignment Balance Classification |
| title | Development and validation of a novel classification for characterizing degenerative spondylolisthesis of lumbar spine |
| title_full | Development and validation of a novel classification for characterizing degenerative spondylolisthesis of lumbar spine |
| title_fullStr | Development and validation of a novel classification for characterizing degenerative spondylolisthesis of lumbar spine |
| title_full_unstemmed | Development and validation of a novel classification for characterizing degenerative spondylolisthesis of lumbar spine |
| title_short | Development and validation of a novel classification for characterizing degenerative spondylolisthesis of lumbar spine |
| title_sort | development and validation of a novel classification for characterizing degenerative spondylolisthesis of lumbar spine |
| topic | Degenerative spondylolisthesis of lumbar spine Global alignment Balance Classification |
| url | https://doi.org/10.1038/s41598-025-06298-x |
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