Circulating LncRNA Is Potentially Up-regulated in Coronary Artery Disease
Coronary artery disease (CAD) is one of the leading causes of death and disability all around the world. Recent studies have revealed that aberrantly regulated long non-coding RNA (lncRNA) as one of the main classes of cellular transcript plays a key regulatory role in transcriptional and epigenetic...
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| Language: | English |
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BioMed Central
2018-12-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gi-2018-16-4-e25.pdf |
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| author | Niloofar Avazpour Mohammadreza Hajjari Saeed Yazdankhah Azita Sahni Ali Mohammad Foroughmand |
| author_facet | Niloofar Avazpour Mohammadreza Hajjari Saeed Yazdankhah Azita Sahni Ali Mohammad Foroughmand |
| author_sort | Niloofar Avazpour |
| collection | DOAJ |
| description | Coronary artery disease (CAD) is one of the leading causes of death and disability all around the world. Recent studies have revealed that aberrantly regulated long non-coding RNA (lncRNA) as one of the main classes of cellular transcript plays a key regulatory role in transcriptional and epigenetic pathways. Recent reports have demonstrated that circulating lncRNAs in the blood can be potential biomarkers for CAD. HOTAIR is one of the most cited lncRNAs with a critical role in the initiation and progression of the gene expression regulation. Recent research on the role of the HOTAIR in cardiovascular disease lays the basis for the development of new studies considering this lncRNA as a potential biomarker and therapeutic target in CAD. In this study, we aimed to compare the expression of HOTAIR lncRNA in the blood samples of patients with CAD and control samples. The expression level was examined by semi-quantitative reverse transcriptase polymerase chain reaction technique. Our data shows that expression of HOTAIR is up-regulated in blood samples of patients with CAD. |
| format | Article |
| id | doaj-art-3d961d565e4849899c9a440621fbdc6d |
| institution | Kabale University |
| issn | 2234-0742 |
| language | English |
| publishDate | 2018-12-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-3d961d565e4849899c9a440621fbdc6d2025-02-03T01:34:00ZengBioMed CentralGenomics & Informatics2234-07422018-12-0116410.5808/GI.2018.16.4.e25527Circulating LncRNA Is Potentially Up-regulated in Coronary Artery DiseaseNiloofar Avazpour0Mohammadreza Hajjari1Saeed Yazdankhah2Azita Sahni3Ali Mohammad Foroughmand4 Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz 6135783151, Iran Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz 6135783151, Iran Department of Cardiology, Ahvaz Jundishapur University of Medical Sciences, Imam Khomeini Hospital, Ahvaz 6135783151, Iran Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz 6135783151, Iran Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz 6135783151, IranCoronary artery disease (CAD) is one of the leading causes of death and disability all around the world. Recent studies have revealed that aberrantly regulated long non-coding RNA (lncRNA) as one of the main classes of cellular transcript plays a key regulatory role in transcriptional and epigenetic pathways. Recent reports have demonstrated that circulating lncRNAs in the blood can be potential biomarkers for CAD. HOTAIR is one of the most cited lncRNAs with a critical role in the initiation and progression of the gene expression regulation. Recent research on the role of the HOTAIR in cardiovascular disease lays the basis for the development of new studies considering this lncRNA as a potential biomarker and therapeutic target in CAD. In this study, we aimed to compare the expression of HOTAIR lncRNA in the blood samples of patients with CAD and control samples. The expression level was examined by semi-quantitative reverse transcriptase polymerase chain reaction technique. Our data shows that expression of HOTAIR is up-regulated in blood samples of patients with CAD.http://genominfo.org/upload/pdf/gi-2018-16-4-e25.pdfcoronary artery diseasegene expressionHOTAIRlong noncoding RNA |
| spellingShingle | Niloofar Avazpour Mohammadreza Hajjari Saeed Yazdankhah Azita Sahni Ali Mohammad Foroughmand Circulating LncRNA Is Potentially Up-regulated in Coronary Artery Disease Genomics & Informatics coronary artery disease gene expression HOTAIR long noncoding RNA |
| title | Circulating LncRNA Is Potentially Up-regulated in Coronary Artery Disease |
| title_full | Circulating LncRNA Is Potentially Up-regulated in Coronary Artery Disease |
| title_fullStr | Circulating LncRNA Is Potentially Up-regulated in Coronary Artery Disease |
| title_full_unstemmed | Circulating LncRNA Is Potentially Up-regulated in Coronary Artery Disease |
| title_short | Circulating LncRNA Is Potentially Up-regulated in Coronary Artery Disease |
| title_sort | circulating lncrna is potentially up regulated in coronary artery disease |
| topic | coronary artery disease gene expression HOTAIR long noncoding RNA |
| url | http://genominfo.org/upload/pdf/gi-2018-16-4-e25.pdf |
| work_keys_str_mv | AT niloofaravazpour circulatinglncrnaispotentiallyupregulatedincoronaryarterydisease AT mohammadrezahajjari circulatinglncrnaispotentiallyupregulatedincoronaryarterydisease AT saeedyazdankhah circulatinglncrnaispotentiallyupregulatedincoronaryarterydisease AT azitasahni circulatinglncrnaispotentiallyupregulatedincoronaryarterydisease AT alimohammadforoughmand circulatinglncrnaispotentiallyupregulatedincoronaryarterydisease |