Renal Aspects of Peptic Ulcer Pharmacology

Medications to treat peptic ulcer disease are used widely and may have adverse effects on renal function. Similarly, renal dysfunction may alter the pharmacokinetics of this diverse group of medications resulting in dosage adjustments. The older agents, antacids and sucralfate, allow absorption of c...

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Main Authors: Daniel Muruve, Ellen Burgess
Format: Article
Language:English
Published: Wiley 1992-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/1992/743457
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author Daniel Muruve
Ellen Burgess
author_facet Daniel Muruve
Ellen Burgess
author_sort Daniel Muruve
collection DOAJ
description Medications to treat peptic ulcer disease are used widely and may have adverse effects on renal function. Similarly, renal dysfunction may alter the pharmacokinetics of this diverse group of medications resulting in dosage adjustments. The older agents, antacids and sucralfate, allow absorption of cations (calcium, magnesium and aluminum) which may result in toxicity. Newer medications (H2 blockers and omeprazole) appear to have fewer side effects and be better tolerated with appropriate dosage adjustments.
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spelling doaj-art-3d8baaf174a144c593e87502b7e841f22025-02-03T01:04:53ZengWileyCanadian Journal of Gastroenterology0835-79001992-01-0161293410.1155/1992/743457Renal Aspects of Peptic Ulcer PharmacologyDaniel Muruve0Ellen Burgess1Department of Medicine, University of Calgary, Calgary, Alberta, CanadaDepartment of Medicine, University of Calgary, Calgary, Alberta, CanadaMedications to treat peptic ulcer disease are used widely and may have adverse effects on renal function. Similarly, renal dysfunction may alter the pharmacokinetics of this diverse group of medications resulting in dosage adjustments. The older agents, antacids and sucralfate, allow absorption of cations (calcium, magnesium and aluminum) which may result in toxicity. Newer medications (H2 blockers and omeprazole) appear to have fewer side effects and be better tolerated with appropriate dosage adjustments.http://dx.doi.org/10.1155/1992/743457
spellingShingle Daniel Muruve
Ellen Burgess
Renal Aspects of Peptic Ulcer Pharmacology
Canadian Journal of Gastroenterology
title Renal Aspects of Peptic Ulcer Pharmacology
title_full Renal Aspects of Peptic Ulcer Pharmacology
title_fullStr Renal Aspects of Peptic Ulcer Pharmacology
title_full_unstemmed Renal Aspects of Peptic Ulcer Pharmacology
title_short Renal Aspects of Peptic Ulcer Pharmacology
title_sort renal aspects of peptic ulcer pharmacology
url http://dx.doi.org/10.1155/1992/743457
work_keys_str_mv AT danielmuruve renalaspectsofpepticulcerpharmacology
AT ellenburgess renalaspectsofpepticulcerpharmacology