Divergent effects of PERK and IRE1 signaling on cell viability.

Divergent effects of PERK and IRE1 signaling on cell viability.

Protein misfolding in the endoplasmic reticulum (ER) activates a set of intracellular signaling pathways, collectively termed the Unfolded Protein Response (UPR). UPR signaling promotes cell survival by reducing misfolded protein levels. If homeostasis cannot be restored, UPR signaling promotes cell...

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Bibliographic Details
Main Authors: Jonathan H Lin, Han Li, Yuhong Zhang, David Ron, Peter Walter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0004170&type=printable
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