A biorthogonal chemistry approach for high-contrast antibody imaging of lymphoma at early time points

A biorthogonal chemistry approach for high-contrast antibody imaging of lymphoma at early time points

Abstract Background Monoclonal antibodies are highly specific for their targets making them effective for cancer therapy. However, their large molecular weight causes slow blood clearance, often requiring weeks to be removed from circulation. This limitation affects companion nuclear imaging and ant...

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Main Authors: Swarbhanu Sarkar, Jonathan M. Pham, Kimberly J. Edwards, Nitika Sharma, Kexiang Xu, A. Paden King, Andres Fernandez del Castillo, Michael D. Farwell, Daniel A. Pryma, Stephen J. Schuster, Mark A. Sellmyer
Format: Article
Language:English
Published: SpringerOpen 2025-03-01
Series:EJNMMI Research
Subjects:
Radioimmunoconjugate
Click chemistry
Biorthogonal
Tumor imaging
Online Access:https://doi.org/10.1186/s13550-025-01213-x
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