Integrative miRNA-mRNA profiling uncovers mechanisms of belimumab action in systemic lupus erythematosus

Integrative miRNA-mRNA profiling uncovers mechanisms of belimumab action in systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder driven by autoreactive B cells and characterized by the production of pathogenic autoantibodies. Belimumab, an anti-BAFF monoclonal antibody, has demonstrated efficacy in reducing disease activity and corticosteroid use in SLE patie...

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Bibliographic Details
Main Authors: Maria Royo, Blanca Joseph-Mullol, Sebastian Sandoval, Teresa Moliné, Cristina Solé, Josefina Cortés-Hernández
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus
miRNA
mRNA
integrative “omics”
belimumab
mechanism of action
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1553971/full
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