ABO Blood Groups and Cardiovascular Diseases
ABO blood groups have been associated with various disease phenotypes, particularly cardiovascular diseases. Cardiovascular diseases are the most common causes of death in developed countries and their prevalence rate is rapidly growing in developing countries. There have been substantial historical...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/641917 |
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| _version_ | 1832565849480757248 |
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| author | Hanrui Zhang Ciarán J. Mooney Muredach P. Reilly |
| author_facet | Hanrui Zhang Ciarán J. Mooney Muredach P. Reilly |
| author_sort | Hanrui Zhang |
| collection | DOAJ |
| description | ABO blood groups have been associated with various disease phenotypes, particularly cardiovascular diseases. Cardiovascular diseases are the most common causes of death in developed countries and their prevalence rate is rapidly growing in developing countries. There have been substantial historical associations between non-O blood group status and an increase in some cardiovascular disorders. Recent GWASs have identified ABO as a locus for thrombosis, myocardial infarction, and multiple cardiovascular risk biomarkers, refocusing attention on mechanisms and potential for clinical advances. As we highlight in this paper, more recent work is beginning to probe the molecular basis of the disease associations observed in these observational studies. Advances in our understanding of the physiologic importance of various endothelial and platelet-derived circulating glycoproteins are elucidating the mechanisms through which the ABO blood group may determine overall cardiovascular disease risk. The role of blood group antigens in the pathogenesis of various cardiovascular disorders remains a fascinating subject with potential to lead to novel therapeutics and prognostics and to reduce the global burden of cardiovascular diseases. |
| format | Article |
| id | doaj-art-3d7cea1502b3479e8858d16ae523c314 |
| institution | Kabale University |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-3d7cea1502b3479e8858d16ae523c3142025-02-03T01:06:20ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322012-01-01201210.1155/2012/641917641917ABO Blood Groups and Cardiovascular DiseasesHanrui Zhang0Ciarán J. Mooney1Muredach P. Reilly2Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USACardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USACardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USAABO blood groups have been associated with various disease phenotypes, particularly cardiovascular diseases. Cardiovascular diseases are the most common causes of death in developed countries and their prevalence rate is rapidly growing in developing countries. There have been substantial historical associations between non-O blood group status and an increase in some cardiovascular disorders. Recent GWASs have identified ABO as a locus for thrombosis, myocardial infarction, and multiple cardiovascular risk biomarkers, refocusing attention on mechanisms and potential for clinical advances. As we highlight in this paper, more recent work is beginning to probe the molecular basis of the disease associations observed in these observational studies. Advances in our understanding of the physiologic importance of various endothelial and platelet-derived circulating glycoproteins are elucidating the mechanisms through which the ABO blood group may determine overall cardiovascular disease risk. The role of blood group antigens in the pathogenesis of various cardiovascular disorders remains a fascinating subject with potential to lead to novel therapeutics and prognostics and to reduce the global burden of cardiovascular diseases.http://dx.doi.org/10.1155/2012/641917 |
| spellingShingle | Hanrui Zhang Ciarán J. Mooney Muredach P. Reilly ABO Blood Groups and Cardiovascular Diseases International Journal of Vascular Medicine |
| title | ABO Blood Groups and Cardiovascular Diseases |
| title_full | ABO Blood Groups and Cardiovascular Diseases |
| title_fullStr | ABO Blood Groups and Cardiovascular Diseases |
| title_full_unstemmed | ABO Blood Groups and Cardiovascular Diseases |
| title_short | ABO Blood Groups and Cardiovascular Diseases |
| title_sort | abo blood groups and cardiovascular diseases |
| url | http://dx.doi.org/10.1155/2012/641917 |
| work_keys_str_mv | AT hanruizhang abobloodgroupsandcardiovasculardiseases AT ciaranjmooney abobloodgroupsandcardiovasculardiseases AT muredachpreilly abobloodgroupsandcardiovasculardiseases |