Clinical utility of anti-cyclic citrullinated peptid and rheumatoid factor in chronic hepatitis B virus infection
Background: It is necessary to distinguish whether musculoskeletal symptoms are associated with rheumatic diseases or hepatitis virus infection. Rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) may be detected in rheumatic diseases and also during infections. The objective of...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2018-01-01
|
| Series: | Indian Journal of Rheumatology |
| Subjects: | |
| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2018;volume=13;issue=4;spage=229;epage=232;aulast=Sargin |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832544048567549952 |
|---|---|
| author | Gokhan Sargin Altay Kandemir |
| author_facet | Gokhan Sargin Altay Kandemir |
| author_sort | Gokhan Sargin |
| collection | DOAJ |
| description | Background: It is necessary to distinguish whether musculoskeletal symptoms are associated with rheumatic diseases or hepatitis virus infection. Rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) may be detected in rheumatic diseases and also during infections. The objective of this study was to evaluate the clinical utility of anti-CCP and RF in patients with chronic hepatitis B virus (HBV) infection.
Methods: Ninety-seven patients with chronic HBV infection, 35 patients with rheumatoid arthritis (RA), and 30 healthy controls were included in the study. HBV-DNA, hepatitis B e antigen, anti-HBe, RF, and anti-CCP were evaluated.
Results: The rates of positivity for RF and anti-CCP were 14.4% and 4.1% respectively in patients with chronic HBV infection. Arthritis was present in 7 of 97 patients with chronic HBV infection. There was a statistically significant difference for anti-CCP positivity but not for RF positivity between patients with arthritis and without arthritis. No correlation was found between RF and anti-CCP, HBV-DNA, anti-CCP, and HBV-DNA in patients with HBV infection.
Conclusions: Anti-CCP positivity was a determinant for polyarthritis in the context of HBV infection. It appears to be a more reliable parameter than RF in differentiating arthritis and nonarthritis group in patients with HBV infection. |
| format | Article |
| id | doaj-art-3d7a6909b5b2460bb968217398f67204 |
| institution | Kabale University |
| issn | 0973-3698 0973-3701 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Rheumatology |
| spelling | doaj-art-3d7a6909b5b2460bb968217398f672042025-02-03T11:07:28ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012018-01-0113422923210.4103/injr.injr_82_18Clinical utility of anti-cyclic citrullinated peptid and rheumatoid factor in chronic hepatitis B virus infectionGokhan SarginAltay KandemirBackground: It is necessary to distinguish whether musculoskeletal symptoms are associated with rheumatic diseases or hepatitis virus infection. Rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) may be detected in rheumatic diseases and also during infections. The objective of this study was to evaluate the clinical utility of anti-CCP and RF in patients with chronic hepatitis B virus (HBV) infection. Methods: Ninety-seven patients with chronic HBV infection, 35 patients with rheumatoid arthritis (RA), and 30 healthy controls were included in the study. HBV-DNA, hepatitis B e antigen, anti-HBe, RF, and anti-CCP were evaluated. Results: The rates of positivity for RF and anti-CCP were 14.4% and 4.1% respectively in patients with chronic HBV infection. Arthritis was present in 7 of 97 patients with chronic HBV infection. There was a statistically significant difference for anti-CCP positivity but not for RF positivity between patients with arthritis and without arthritis. No correlation was found between RF and anti-CCP, HBV-DNA, anti-CCP, and HBV-DNA in patients with HBV infection. Conclusions: Anti-CCP positivity was a determinant for polyarthritis in the context of HBV infection. It appears to be a more reliable parameter than RF in differentiating arthritis and nonarthritis group in patients with HBV infection.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2018;volume=13;issue=4;spage=229;epage=232;aulast=SarginAnti-cyclic citrullinatedclinical significancehepatitis Brheumatoid factor |
| spellingShingle | Gokhan Sargin Altay Kandemir Clinical utility of anti-cyclic citrullinated peptid and rheumatoid factor in chronic hepatitis B virus infection Indian Journal of Rheumatology Anti-cyclic citrullinated clinical significance hepatitis B rheumatoid factor |
| title | Clinical utility of anti-cyclic citrullinated peptid and rheumatoid factor in chronic hepatitis B virus infection |
| title_full | Clinical utility of anti-cyclic citrullinated peptid and rheumatoid factor in chronic hepatitis B virus infection |
| title_fullStr | Clinical utility of anti-cyclic citrullinated peptid and rheumatoid factor in chronic hepatitis B virus infection |
| title_full_unstemmed | Clinical utility of anti-cyclic citrullinated peptid and rheumatoid factor in chronic hepatitis B virus infection |
| title_short | Clinical utility of anti-cyclic citrullinated peptid and rheumatoid factor in chronic hepatitis B virus infection |
| title_sort | clinical utility of anti cyclic citrullinated peptid and rheumatoid factor in chronic hepatitis b virus infection |
| topic | Anti-cyclic citrullinated clinical significance hepatitis B rheumatoid factor |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2018;volume=13;issue=4;spage=229;epage=232;aulast=Sargin |
| work_keys_str_mv | AT gokhansargin clinicalutilityofanticycliccitrullinatedpeptidandrheumatoidfactorinchronichepatitisbvirusinfection AT altaykandemir clinicalutilityofanticycliccitrullinatedpeptidandrheumatoidfactorinchronichepatitisbvirusinfection |