The Role of Peroxisome Proliferator-Activated Receptors in Pulmonary Vascular Disease
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily that regulate diverse physiological processes ranging from lipogenesis to inflammation. Recent evidence has established potential roles of PPARs in bot...
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2007/18797 |
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| _version_ | 1832558235289124864 |
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| author | Rachel E. Nisbet Roy L. Sutliff C. Michael Hart |
| author_facet | Rachel E. Nisbet Roy L. Sutliff C. Michael Hart |
| author_sort | Rachel E. Nisbet |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily that regulate diverse physiological processes ranging from lipogenesis to inflammation. Recent evidence has established potential roles of PPARs in both systemic and pulmonary vascular disease and function. Existing treatment strategies for pulmonary hypertension, the most common manifestation of pulmonary vascular disease, are limited by an incomplete understanding of the underlying disease pathogenesis and lack of efficacy indicating an urgent need for new approaches to treat this disorder. Derangements in pulmonary endothelial-derived mediators and endothelial dysfunction have been shown to play a pivotal role in pulmonary hypertension pathogenesis. Therefore, the following review will focus on selected mediators implicated in pulmonary vascular dysfunction and evidence that PPARs, in particular PPARγ, participate in their regulation and may provide a potential novel therapeutic target for the treatment of pulmonary hypertension. |
| format | Article |
| id | doaj-art-3d74490e3a284563b93ee68155478ade |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-3d74490e3a284563b93ee68155478ade2025-02-03T01:32:50ZengWileyPPAR Research1687-47571687-47652007-01-01200710.1155/2007/1879718797The Role of Peroxisome Proliferator-Activated Receptors in Pulmonary Vascular DiseaseRachel E. Nisbet0Roy L. Sutliff1C. Michael Hart2Department of Medicine, Emory University, Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USADepartment of Medicine, Emory University, Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USADepartment of Medicine, Emory University, Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USAPeroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily that regulate diverse physiological processes ranging from lipogenesis to inflammation. Recent evidence has established potential roles of PPARs in both systemic and pulmonary vascular disease and function. Existing treatment strategies for pulmonary hypertension, the most common manifestation of pulmonary vascular disease, are limited by an incomplete understanding of the underlying disease pathogenesis and lack of efficacy indicating an urgent need for new approaches to treat this disorder. Derangements in pulmonary endothelial-derived mediators and endothelial dysfunction have been shown to play a pivotal role in pulmonary hypertension pathogenesis. Therefore, the following review will focus on selected mediators implicated in pulmonary vascular dysfunction and evidence that PPARs, in particular PPARγ, participate in their regulation and may provide a potential novel therapeutic target for the treatment of pulmonary hypertension.http://dx.doi.org/10.1155/2007/18797 |
| spellingShingle | Rachel E. Nisbet Roy L. Sutliff C. Michael Hart The Role of Peroxisome Proliferator-Activated Receptors in Pulmonary Vascular Disease PPAR Research |
| title | The Role of Peroxisome Proliferator-Activated Receptors in Pulmonary Vascular Disease |
| title_full | The Role of Peroxisome Proliferator-Activated Receptors in Pulmonary Vascular Disease |
| title_fullStr | The Role of Peroxisome Proliferator-Activated Receptors in Pulmonary Vascular Disease |
| title_full_unstemmed | The Role of Peroxisome Proliferator-Activated Receptors in Pulmonary Vascular Disease |
| title_short | The Role of Peroxisome Proliferator-Activated Receptors in Pulmonary Vascular Disease |
| title_sort | role of peroxisome proliferator activated receptors in pulmonary vascular disease |
| url | http://dx.doi.org/10.1155/2007/18797 |
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