Association between Uric Acid and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes Mellitus in China: A Cross-Sectional Inpatient Study
Objective. To analyze the association between uric acid levels and bone mineral density in postmenopausal women with type 2 diabetes mellitus. Methods. We retrospectively analyzed 262 postmenopausal women with type 2 diabetes mellitus, to assess uric acid levels and bone mineral density using the T...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/3982831 |
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| author | Xin Zhao Xiaofeng Yu Xiaomei Zhang |
| author_facet | Xin Zhao Xiaofeng Yu Xiaomei Zhang |
| author_sort | Xin Zhao |
| collection | DOAJ |
| description | Objective. To analyze the association between uric acid levels and bone mineral density in postmenopausal women with type 2 diabetes mellitus. Methods. We retrospectively analyzed 262 postmenopausal women with type 2 diabetes mellitus, to assess uric acid levels and bone mineral density using the T score of dual-energy X-ray absorptiometry. Results. (1) Women in the osteoporosis group demonstrated higher uric acid levels and lower estimated glomerular filtration rate (p<0.05, respectively). (2) Uric acid levels were positively correlated with the hip and lumbar spine bone mineral density and T score (r=0.17, p<0.05; r=0.25, p<0.05; r=0.17, p<0.05; and r=0.28, p<0.05, respectively). Meanwhile, there was a positive relation between estimated glomerular filtration rate and hip bone mineral density (r=0.22, p<0.05). (3) Logistic regression analysis showed that age, body mass index, and diabetic duration are independent risk factors for osteoporosis in postmenopausal women with type 2 diabetes mellitus. The level of estimated glomerular filtration rate and uric acid levels were not independent effect factors for osteoporosis in menopausal women. Conclusion. Uric acid levels are neither a protective factor nor a risk factor for osteoporosis in women with type 2 diabetes mellitus. |
| format | Article |
| id | doaj-art-3d706edc278141c4b765316f25f9b2ad |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-3d706edc278141c4b765316f25f9b2ad2025-02-03T05:51:10ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/39828313982831Association between Uric Acid and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes Mellitus in China: A Cross-Sectional Inpatient StudyXin Zhao0Xiaofeng Yu1Xiaomei Zhang2Endocrinology Department, Peking University International Hospital, Beijing, ChinaEndocrinology Department, Peking University International Hospital, Beijing, ChinaEndocrinology Department, Peking University International Hospital, Beijing, ChinaObjective. To analyze the association between uric acid levels and bone mineral density in postmenopausal women with type 2 diabetes mellitus. Methods. We retrospectively analyzed 262 postmenopausal women with type 2 diabetes mellitus, to assess uric acid levels and bone mineral density using the T score of dual-energy X-ray absorptiometry. Results. (1) Women in the osteoporosis group demonstrated higher uric acid levels and lower estimated glomerular filtration rate (p<0.05, respectively). (2) Uric acid levels were positively correlated with the hip and lumbar spine bone mineral density and T score (r=0.17, p<0.05; r=0.25, p<0.05; r=0.17, p<0.05; and r=0.28, p<0.05, respectively). Meanwhile, there was a positive relation between estimated glomerular filtration rate and hip bone mineral density (r=0.22, p<0.05). (3) Logistic regression analysis showed that age, body mass index, and diabetic duration are independent risk factors for osteoporosis in postmenopausal women with type 2 diabetes mellitus. The level of estimated glomerular filtration rate and uric acid levels were not independent effect factors for osteoporosis in menopausal women. Conclusion. Uric acid levels are neither a protective factor nor a risk factor for osteoporosis in women with type 2 diabetes mellitus.http://dx.doi.org/10.1155/2020/3982831 |
| spellingShingle | Xin Zhao Xiaofeng Yu Xiaomei Zhang Association between Uric Acid and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes Mellitus in China: A Cross-Sectional Inpatient Study Journal of Diabetes Research |
| title | Association between Uric Acid and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes Mellitus in China: A Cross-Sectional Inpatient Study |
| title_full | Association between Uric Acid and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes Mellitus in China: A Cross-Sectional Inpatient Study |
| title_fullStr | Association between Uric Acid and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes Mellitus in China: A Cross-Sectional Inpatient Study |
| title_full_unstemmed | Association between Uric Acid and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes Mellitus in China: A Cross-Sectional Inpatient Study |
| title_short | Association between Uric Acid and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes Mellitus in China: A Cross-Sectional Inpatient Study |
| title_sort | association between uric acid and bone mineral density in postmenopausal women with type 2 diabetes mellitus in china a cross sectional inpatient study |
| url | http://dx.doi.org/10.1155/2020/3982831 |
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