CpG Oligodeoxynucleotides Enhance the Efficacy of Adoptive Cell Transfer Using Tumor Infiltrating Lymphocytes by Modifying the Th1 Polarization and Local Infiltration of Th17 Cells
Adoptive cell transfer immunotherapy using tumor infiltrating lymphocytes (TILs) was an important therapeutic strategy against tumors. But the efficacy remains limited and development of new strategies is urgent. Recent evidence suggested that CpG-ODNs might be a potent candidate for tumor immunothe...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2010/410893 |
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| author | Lin Xu Chunhong Wang Zhenke Wen Ya Zhou Zhongmin Liu Yongjie Liang Zengguang Xu Tao Ren |
| author_facet | Lin Xu Chunhong Wang Zhenke Wen Ya Zhou Zhongmin Liu Yongjie Liang Zengguang Xu Tao Ren |
| author_sort | Lin Xu |
| collection | DOAJ |
| description | Adoptive cell transfer immunotherapy using tumor infiltrating lymphocytes (TILs) was an important therapeutic strategy against tumors. But the efficacy remains limited and development of new strategies is urgent. Recent evidence suggested that CpG-ODNs might be a potent candidate for tumor immunotherapy. Here we firstly reported that CpG-ODNs could significantly enhance the antitumor efficacy of adoptively transferred TILs in vivo accompanied by enhanced activity capacity and proliferation of CD8+ T cells and CD8+ T cells, as well as a Th1 polarization immune response. Most importantly, we found that CpG-ODNs could significantly elevate the infiltration of Th17 cells in tumor mass, which contributed to anti-tumor efficacy of TILs in vivo. Our findings suggested that CpG ODNs could enhance the anti-tumor efficacy of adoptively transferred TILs through modifying Th1 polarization and local infiltration of Th17 cells, which might provide a clue for developing a new strategy for ACT based on TILs. |
| format | Article |
| id | doaj-art-3d7032d9146c48adabb37610f250eeff |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-3d7032d9146c48adabb37610f250eeff2025-02-03T01:25:29ZengWileyClinical and Developmental Immunology1740-25221740-25302010-01-01201010.1155/2010/410893410893CpG Oligodeoxynucleotides Enhance the Efficacy of Adoptive Cell Transfer Using Tumor Infiltrating Lymphocytes by Modifying the Th1 Polarization and Local Infiltration of Th17 CellsLin Xu0Chunhong Wang1Zhenke Wen2Ya Zhou3Zhongmin Liu4Yongjie Liang5Zengguang Xu6Tao Ren7Department of Immunology, Zunyi Medical College, Guizhou 563003, ChinaDepartment of Chest Medicine, Qingdao Chest Hospital, Shandong 266043, ChinaInstitute for Immunobiology and Department of Immunology, Shanghai Medical College, Fudan University, Shanghai 200032, ChinaDepartment of Medical Physics, Zunyi Medical College, Guizhou 563003, ChinaDepartment of Cardiothoracic Surgery, East Hospital, Tongji Unversity School of Medicine, Shanghai 200120, ChinaDepartment of Respiratory Medicine, East Hospital, Tongji Unversity School of Medicine, 150 Jimo Road, Pudong New Area, Shanghai 200120, ChinaDepartment of Scientific Research, East Hospital, Tongji Unversity School of Medicine, Shanghai 200120, ChinaDepartment of Respiratory Medicine, East Hospital, Tongji Unversity School of Medicine, 150 Jimo Road, Pudong New Area, Shanghai 200120, ChinaAdoptive cell transfer immunotherapy using tumor infiltrating lymphocytes (TILs) was an important therapeutic strategy against tumors. But the efficacy remains limited and development of new strategies is urgent. Recent evidence suggested that CpG-ODNs might be a potent candidate for tumor immunotherapy. Here we firstly reported that CpG-ODNs could significantly enhance the antitumor efficacy of adoptively transferred TILs in vivo accompanied by enhanced activity capacity and proliferation of CD8+ T cells and CD8+ T cells, as well as a Th1 polarization immune response. Most importantly, we found that CpG-ODNs could significantly elevate the infiltration of Th17 cells in tumor mass, which contributed to anti-tumor efficacy of TILs in vivo. Our findings suggested that CpG ODNs could enhance the anti-tumor efficacy of adoptively transferred TILs through modifying Th1 polarization and local infiltration of Th17 cells, which might provide a clue for developing a new strategy for ACT based on TILs.http://dx.doi.org/10.1155/2010/410893 |
| spellingShingle | Lin Xu Chunhong Wang Zhenke Wen Ya Zhou Zhongmin Liu Yongjie Liang Zengguang Xu Tao Ren CpG Oligodeoxynucleotides Enhance the Efficacy of Adoptive Cell Transfer Using Tumor Infiltrating Lymphocytes by Modifying the Th1 Polarization and Local Infiltration of Th17 Cells Clinical and Developmental Immunology |
| title | CpG Oligodeoxynucleotides Enhance the Efficacy of Adoptive Cell Transfer Using Tumor Infiltrating Lymphocytes by Modifying the Th1 Polarization and Local Infiltration of Th17 Cells |
| title_full | CpG Oligodeoxynucleotides Enhance the Efficacy of Adoptive Cell Transfer Using Tumor Infiltrating Lymphocytes by Modifying the Th1 Polarization and Local Infiltration of Th17 Cells |
| title_fullStr | CpG Oligodeoxynucleotides Enhance the Efficacy of Adoptive Cell Transfer Using Tumor Infiltrating Lymphocytes by Modifying the Th1 Polarization and Local Infiltration of Th17 Cells |
| title_full_unstemmed | CpG Oligodeoxynucleotides Enhance the Efficacy of Adoptive Cell Transfer Using Tumor Infiltrating Lymphocytes by Modifying the Th1 Polarization and Local Infiltration of Th17 Cells |
| title_short | CpG Oligodeoxynucleotides Enhance the Efficacy of Adoptive Cell Transfer Using Tumor Infiltrating Lymphocytes by Modifying the Th1 Polarization and Local Infiltration of Th17 Cells |
| title_sort | cpg oligodeoxynucleotides enhance the efficacy of adoptive cell transfer using tumor infiltrating lymphocytes by modifying the th1 polarization and local infiltration of th17 cells |
| url | http://dx.doi.org/10.1155/2010/410893 |
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