Hemophagocytic lymphohistiocytosis associated with oxcarbazepine
Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening multisystem disorder. Reports of the disorder as a side effect of drugs are extremely rare. We report the case of a 3-year-old boy with a history of epileptic seizures in which oxcarbazepine was added to treatment for the last 35 d...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2019-04-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/692 |
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| author | Serkan Kırık Hatice Güneş Sadık Yurttutan Nafiz Sarışık Can Acıpayam Yasemin Kırık |
| author_facet | Serkan Kırık Hatice Güneş Sadık Yurttutan Nafiz Sarışık Can Acıpayam Yasemin Kırık |
| author_sort | Serkan Kırık |
| collection | DOAJ |
| description |
Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening multisystem disorder. Reports of the disorder as a side effect of drugs are extremely rare. We report the case of a 3-year-old boy with a history of epileptic seizures in which oxcarbazepine was added to treatment for the last 35 days and dose had been increased. For 10 days he had a fever, hepatosplenomegaly, rash, edema and other systemic symptoms. He was diagnosed with HLH after bone marrow examination. Oxcarbazepine treatment was terminated after the intravenous immunoglobulin treatment. The next day, clinical and laboratory results had improved. This is the first HLH report of an association with oxcarbazepine. Bone marrow aspiration may be indicated to confirm the diagnosis when facing a patient with systemic symptoms after newly added antiepileptic drug treatment.
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| format | Article |
| id | doaj-art-3d6a73b19b354878adb1ed10ed7cc2ec |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2019-04-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-3d6a73b19b354878adb1ed10ed7cc2ec2025-08-20T02:01:47ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212019-04-0161210.24953/turkjped.2019.02.025Hemophagocytic lymphohistiocytosis associated with oxcarbazepineSerkan Kırık0Hatice Güneş1Sadık Yurttutan2Nafiz Sarışık3Can Acıpayam4Yasemin Kırık5Departments of Pediatric Neurology, Kahramanmaras Sutcu Imam University, Faculty of Medicine, Kahramanmaras, Turkey.Departments of Pediatrics, Kahramanmaras Sutcu Imam University, Faculty of Medicine, Kahramanmaras, Turkey.Departments of Pediatrics, Kahramanmaras Sutcu Imam University, Faculty of Medicine, Kahramanmaras, Turkey.Departments of Pediatrics, Kahramanmaras Sutcu Imam University, Faculty of Medicine, Kahramanmaras, Turkey.Departments of Pediatrics, Kahramanmaras Sutcu Imam University, Faculty of Medicine, Kahramanmaras, Turkey.Department of Infectious Diseases and Clinical Microbiology, Necip Fazıl State Hospital, Kahramanmaras, Turkey. Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening multisystem disorder. Reports of the disorder as a side effect of drugs are extremely rare. We report the case of a 3-year-old boy with a history of epileptic seizures in which oxcarbazepine was added to treatment for the last 35 days and dose had been increased. For 10 days he had a fever, hepatosplenomegaly, rash, edema and other systemic symptoms. He was diagnosed with HLH after bone marrow examination. Oxcarbazepine treatment was terminated after the intravenous immunoglobulin treatment. The next day, clinical and laboratory results had improved. This is the first HLH report of an association with oxcarbazepine. Bone marrow aspiration may be indicated to confirm the diagnosis when facing a patient with systemic symptoms after newly added antiepileptic drug treatment. https://turkjpediatr.org/article/view/692epilepsyhemophagocytic lymphohistiocytosisoxcarbazepine |
| spellingShingle | Serkan Kırık Hatice Güneş Sadık Yurttutan Nafiz Sarışık Can Acıpayam Yasemin Kırık Hemophagocytic lymphohistiocytosis associated with oxcarbazepine The Turkish Journal of Pediatrics epilepsy hemophagocytic lymphohistiocytosis oxcarbazepine |
| title | Hemophagocytic lymphohistiocytosis associated with oxcarbazepine |
| title_full | Hemophagocytic lymphohistiocytosis associated with oxcarbazepine |
| title_fullStr | Hemophagocytic lymphohistiocytosis associated with oxcarbazepine |
| title_full_unstemmed | Hemophagocytic lymphohistiocytosis associated with oxcarbazepine |
| title_short | Hemophagocytic lymphohistiocytosis associated with oxcarbazepine |
| title_sort | hemophagocytic lymphohistiocytosis associated with oxcarbazepine |
| topic | epilepsy hemophagocytic lymphohistiocytosis oxcarbazepine |
| url | https://turkjpediatr.org/article/view/692 |
| work_keys_str_mv | AT serkankırık hemophagocyticlymphohistiocytosisassociatedwithoxcarbazepine AT haticegunes hemophagocyticlymphohistiocytosisassociatedwithoxcarbazepine AT sadıkyurttutan hemophagocyticlymphohistiocytosisassociatedwithoxcarbazepine AT nafizsarısık hemophagocyticlymphohistiocytosisassociatedwithoxcarbazepine AT canacıpayam hemophagocyticlymphohistiocytosisassociatedwithoxcarbazepine AT yaseminkırık hemophagocyticlymphohistiocytosisassociatedwithoxcarbazepine |