New Therapeutic Approaches for the Treatment of Rheumatoid Arthritis may Rise from the Cholinergic Anti-Inflammatory Pathway and Antinociceptive Pathway
Due to the complex etiology of rheumatoid arthritis (RA), it is difficult to be completely cured at the current stage although many approaches have been applied in clinics, especially the wide application of nonsteroidal anti-inflammatory drugs (NSAIDs) and disease-modifying antirheumatic drugs (DMA...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2010.207 |
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| _version_ | 1832561829078892544 |
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| author | Xiao Hua Pan Jianxin Zhang Xiaowei Yu Ling Qin Ligeng Kang Peng Zhang |
| author_facet | Xiao Hua Pan Jianxin Zhang Xiaowei Yu Ling Qin Ligeng Kang Peng Zhang |
| author_sort | Xiao Hua Pan |
| collection | DOAJ |
| description | Due to the complex etiology of rheumatoid arthritis (RA), it is difficult to be completely cured at the current stage although many approaches have been applied in clinics, especially the wide application of nonsteroidal anti-inflammatory drugs (NSAIDs) and disease-modifying antirheumatic drugs (DMARDs). New drug discovery and development via the recently discovered cholinergic anti-inflammatory and antinociceptive pathways should be promising. Based on the above, the nicotinic acetylcholine receptor agonists maintain the potential for the treatment of RA. Therefore, new therapeutic approaches may rise from these two newly discovered pathways. More preclinical experiments and clinical trials are required to confirm our viewpoint. |
| format | Article |
| id | doaj-art-3d5a381754244b2288959810e33004bb |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-3d5a381754244b2288959810e33004bb2025-02-03T01:24:03ZengWileyThe Scientific World Journal1537-744X2010-01-01102248225310.1100/tsw.2010.207New Therapeutic Approaches for the Treatment of Rheumatoid Arthritis may Rise from the Cholinergic Anti-Inflammatory Pathway and Antinociceptive PathwayXiao Hua Pan0Jianxin Zhang1Xiaowei Yu2Ling Qin3Ligeng Kang4Peng Zhang5Department of Orthopaedics, Second Clinical Medical College, Jinan University, Shenzhen, Guangdong Province, ChinaDepartment of Orthopaedics, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, ChinaDepartment of Orthopaedics, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, ChinaCenter for Translational Medicine Research and Development, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong Province, ChinaDepartment of Orthopaedics, Taian Hospital of Traditional Chinese Medicine, Taian, Shandong Province, ChinaCenter for Translational Medicine Research and Development, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong Province, ChinaDue to the complex etiology of rheumatoid arthritis (RA), it is difficult to be completely cured at the current stage although many approaches have been applied in clinics, especially the wide application of nonsteroidal anti-inflammatory drugs (NSAIDs) and disease-modifying antirheumatic drugs (DMARDs). New drug discovery and development via the recently discovered cholinergic anti-inflammatory and antinociceptive pathways should be promising. Based on the above, the nicotinic acetylcholine receptor agonists maintain the potential for the treatment of RA. Therefore, new therapeutic approaches may rise from these two newly discovered pathways. More preclinical experiments and clinical trials are required to confirm our viewpoint.http://dx.doi.org/10.1100/tsw.2010.207 |
| spellingShingle | Xiao Hua Pan Jianxin Zhang Xiaowei Yu Ling Qin Ligeng Kang Peng Zhang New Therapeutic Approaches for the Treatment of Rheumatoid Arthritis may Rise from the Cholinergic Anti-Inflammatory Pathway and Antinociceptive Pathway The Scientific World Journal |
| title | New Therapeutic Approaches for the Treatment of Rheumatoid Arthritis may Rise from the Cholinergic Anti-Inflammatory Pathway and Antinociceptive Pathway |
| title_full | New Therapeutic Approaches for the Treatment of Rheumatoid Arthritis may Rise from the Cholinergic Anti-Inflammatory Pathway and Antinociceptive Pathway |
| title_fullStr | New Therapeutic Approaches for the Treatment of Rheumatoid Arthritis may Rise from the Cholinergic Anti-Inflammatory Pathway and Antinociceptive Pathway |
| title_full_unstemmed | New Therapeutic Approaches for the Treatment of Rheumatoid Arthritis may Rise from the Cholinergic Anti-Inflammatory Pathway and Antinociceptive Pathway |
| title_short | New Therapeutic Approaches for the Treatment of Rheumatoid Arthritis may Rise from the Cholinergic Anti-Inflammatory Pathway and Antinociceptive Pathway |
| title_sort | new therapeutic approaches for the treatment of rheumatoid arthritis may rise from the cholinergic anti inflammatory pathway and antinociceptive pathway |
| url | http://dx.doi.org/10.1100/tsw.2010.207 |
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