Possible Roles of IL-33 in the Innate-Adaptive Immune Crosstalk of Psoriasis Pathogenesis
Background. IL-33 belongs to the IL-1 family, playing a role in several biologic processes as well as in the pathogenesis of different diseases, including skin pathologies. It acts as an alarmin, released by damaged cells. Binding to a ST2 receptor, it stimulates many immune cells such as ILC2 and T...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/7158014 |
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| author | Serafinella Patrizia Cannavò Lucrezia Bertino Eleonora Di Salvo Valeria Papaianni Elvira Ventura-Spagnolo Sebastiano Gangemi |
| author_facet | Serafinella Patrizia Cannavò Lucrezia Bertino Eleonora Di Salvo Valeria Papaianni Elvira Ventura-Spagnolo Sebastiano Gangemi |
| author_sort | Serafinella Patrizia Cannavò |
| collection | DOAJ |
| description | Background. IL-33 belongs to the IL-1 family, playing a role in several biologic processes as well as in the pathogenesis of different diseases, including skin pathologies. It acts as an alarmin, released by damaged cells. Binding to a ST2 receptor, it stimulates many immune cells such as ILC2 and Th2 cells. IL-33/ST2 axis seems to be involved in Th17 response. According to this, a review was performed to analyze if IL-33 even interplay in the onset of psoriasis, a Th1/Th17 inflammatory disease. Methods. Data obtained from the included articles are study author name, publication date, group studied, clinical and biological variables, laboratory tests, and outcome of interest of the study. Results. Data are obtained from the 19 studies identified, which assessed the association between IL-33 and psoriasis. Discussion. It seems to promote the innate-adaptive immune crosstalk: it could induce mast cells and neutrophil response after being released by injured keratinocytes and after stimulation by some cytokines, in particular TNFα, INFγ, and IL-17A. In addition, it seems to be involved from the onset of disease to the development of comorbidities, as psoriatic arthritis. Conclusion. The core of the future research on psoriasis could be to fully understand the role of this complex cytokine, in order also to find a new therapeutic approach. |
| format | Article |
| id | doaj-art-3d545ccc61c64865be63185fa162a148 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3d545ccc61c64865be63185fa162a1482025-02-03T05:50:17ZengWileyMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/71580147158014Possible Roles of IL-33 in the Innate-Adaptive Immune Crosstalk of Psoriasis PathogenesisSerafinella Patrizia Cannavò0Lucrezia Bertino1Eleonora Di Salvo2Valeria Papaianni3Elvira Ventura-Spagnolo4Sebastiano Gangemi5Section of Dermatology, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, ItalySection of Dermatology, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, ItalyNational Research Council of Italy (CNR), Institute of Biological Resources and Marine Biotechnologies (IRBIM), Messina, ItalySection of Dermatology, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, ItalyLegal Medicine Section, Department for Health Promotion and Mother-Child Care, University of Palermo, Via del Vespro 129, 90127 Palermo, ItalySchool and Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, ItalyBackground. IL-33 belongs to the IL-1 family, playing a role in several biologic processes as well as in the pathogenesis of different diseases, including skin pathologies. It acts as an alarmin, released by damaged cells. Binding to a ST2 receptor, it stimulates many immune cells such as ILC2 and Th2 cells. IL-33/ST2 axis seems to be involved in Th17 response. According to this, a review was performed to analyze if IL-33 even interplay in the onset of psoriasis, a Th1/Th17 inflammatory disease. Methods. Data obtained from the included articles are study author name, publication date, group studied, clinical and biological variables, laboratory tests, and outcome of interest of the study. Results. Data are obtained from the 19 studies identified, which assessed the association between IL-33 and psoriasis. Discussion. It seems to promote the innate-adaptive immune crosstalk: it could induce mast cells and neutrophil response after being released by injured keratinocytes and after stimulation by some cytokines, in particular TNFα, INFγ, and IL-17A. In addition, it seems to be involved from the onset of disease to the development of comorbidities, as psoriatic arthritis. Conclusion. The core of the future research on psoriasis could be to fully understand the role of this complex cytokine, in order also to find a new therapeutic approach.http://dx.doi.org/10.1155/2019/7158014 |
| spellingShingle | Serafinella Patrizia Cannavò Lucrezia Bertino Eleonora Di Salvo Valeria Papaianni Elvira Ventura-Spagnolo Sebastiano Gangemi Possible Roles of IL-33 in the Innate-Adaptive Immune Crosstalk of Psoriasis Pathogenesis Mediators of Inflammation |
| title | Possible Roles of IL-33 in the Innate-Adaptive Immune Crosstalk of Psoriasis Pathogenesis |
| title_full | Possible Roles of IL-33 in the Innate-Adaptive Immune Crosstalk of Psoriasis Pathogenesis |
| title_fullStr | Possible Roles of IL-33 in the Innate-Adaptive Immune Crosstalk of Psoriasis Pathogenesis |
| title_full_unstemmed | Possible Roles of IL-33 in the Innate-Adaptive Immune Crosstalk of Psoriasis Pathogenesis |
| title_short | Possible Roles of IL-33 in the Innate-Adaptive Immune Crosstalk of Psoriasis Pathogenesis |
| title_sort | possible roles of il 33 in the innate adaptive immune crosstalk of psoriasis pathogenesis |
| url | http://dx.doi.org/10.1155/2019/7158014 |
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