Chemical imaging delineates Aβ plaque polymorphism across the Alzheimer’s disease spectrum

Chemical imaging delineates Aβ plaque polymorphism across the Alzheimer’s disease spectrum

Abstract Amyloid-beta (Aβ) plaque formation in Alzheimer’s disease (AD) pathology is morphologically diverse. Understanding the association of polymorphic Aβ pathology with AD pathogenesis and progression is critical in light of emerging Aβ-targeting therapies. In this work, functional amyloid micro...

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Main Authors: Srinivas Koutarapu, Junyue Ge, Maciej Dulewicz, Meera Srikrishna, Alicja Szadziewska, Jack Wood, Kaj Blennow, Henrik Zetterberg, Wojciech Michno, Natalie S. Ryan, Tammaryn Lashley, Jeffrey N. Savas, Michael Schöll, Jörg Hanrieder
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59085-7
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https://doi.org/10.1038/s41467-025-59085-7

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