Myogenic differentiation markers in muscle tissue after aerobic training
Aerobic training induces a myriad of adaptations in muscle tissue, encompassing alterations in muscle fiber type composition, hypertrophy, and metabolic capacity. Understanding the potential role of myogenic differentiation markers (MDFs), such as Pax7, MyoD, Myogenin, and myosin heavy chain (MHC) i...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025002683 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832573069128892416 |
|---|---|
| author | Rastegar Hoseini Zahra Hoseini Ayob Kamangar |
| author_facet | Rastegar Hoseini Zahra Hoseini Ayob Kamangar |
| author_sort | Rastegar Hoseini |
| collection | DOAJ |
| description | Aerobic training induces a myriad of adaptations in muscle tissue, encompassing alterations in muscle fiber type composition, hypertrophy, and metabolic capacity. Understanding the potential role of myogenic differentiation markers (MDFs), such as Pax7, MyoD, Myogenin, and myosin heavy chain (MHC) isoforms, in mediating these adaptations is of paramount importance. The review delves into the intricate molecular mechanisms underlying the regulation of MDFs following aerobic training, elucidating the role of key signaling pathways including the MAPK/ERK, PI3K/Akt, and AMPK pathways, among others. These pathways play pivotal roles in orchestrating the expression and activity of MDFs, ultimately influencing muscle adaptation and regeneration. The comprehension of MDFs in the context of aerobic training is far-reaching, offering the potential for targeted interventions to optimize muscle adaptation and regeneration. This review identifies the need for further research to unveil the precise molecular mechanisms of the activation and interaction of myogenic differentiation markers with other signaling pathways, as well as to explore their potential as therapeutic targets for muscle-related conditions. This review article also provides a thorough analysis of MDFs in muscle tissue after aerobic training, highlighting their potential clinical implications and outlining future research directions in this area. |
| format | Article |
| id | doaj-art-3d3da17b6dd8423d9bf4881053db7ff2 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-3d3da17b6dd8423d9bf4881053db7ff22025-02-02T05:28:28ZengElsevierHeliyon2405-84402025-01-01112e41888Myogenic differentiation markers in muscle tissue after aerobic trainingRastegar Hoseini0Zahra Hoseini1Ayob Kamangar2Assistant Professor of Exercise Physiology, Department of Exercise Physiology, Faculty of Sport Sciences, Razi University, Kermanshah, Iran; Corresponding author. Department of Exercise Physiology, Faculty of Sport Sciences, Razi University, Kermanshah, Iran.PhD of Exercise Physiology, Department of Exercise Physiology, Faculty of Sport Sciences, Razi University, Kermanshah, IranPhD Student of Exercise Physiology, Department of Exercise Physiology, Faculty of Sport Sciences, Razi University, Kermanshah, IranAerobic training induces a myriad of adaptations in muscle tissue, encompassing alterations in muscle fiber type composition, hypertrophy, and metabolic capacity. Understanding the potential role of myogenic differentiation markers (MDFs), such as Pax7, MyoD, Myogenin, and myosin heavy chain (MHC) isoforms, in mediating these adaptations is of paramount importance. The review delves into the intricate molecular mechanisms underlying the regulation of MDFs following aerobic training, elucidating the role of key signaling pathways including the MAPK/ERK, PI3K/Akt, and AMPK pathways, among others. These pathways play pivotal roles in orchestrating the expression and activity of MDFs, ultimately influencing muscle adaptation and regeneration. The comprehension of MDFs in the context of aerobic training is far-reaching, offering the potential for targeted interventions to optimize muscle adaptation and regeneration. This review identifies the need for further research to unveil the precise molecular mechanisms of the activation and interaction of myogenic differentiation markers with other signaling pathways, as well as to explore their potential as therapeutic targets for muscle-related conditions. This review article also provides a thorough analysis of MDFs in muscle tissue after aerobic training, highlighting their potential clinical implications and outlining future research directions in this area.http://www.sciencedirect.com/science/article/pii/S2405844025002683Myogenic differentiation markersAerobic trainingMuscle adaptationSignaling pathwaysMuscle regeneration |
| spellingShingle | Rastegar Hoseini Zahra Hoseini Ayob Kamangar Myogenic differentiation markers in muscle tissue after aerobic training Heliyon Myogenic differentiation markers Aerobic training Muscle adaptation Signaling pathways Muscle regeneration |
| title | Myogenic differentiation markers in muscle tissue after aerobic training |
| title_full | Myogenic differentiation markers in muscle tissue after aerobic training |
| title_fullStr | Myogenic differentiation markers in muscle tissue after aerobic training |
| title_full_unstemmed | Myogenic differentiation markers in muscle tissue after aerobic training |
| title_short | Myogenic differentiation markers in muscle tissue after aerobic training |
| title_sort | myogenic differentiation markers in muscle tissue after aerobic training |
| topic | Myogenic differentiation markers Aerobic training Muscle adaptation Signaling pathways Muscle regeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025002683 |
| work_keys_str_mv | AT rastegarhoseini myogenicdifferentiationmarkersinmuscletissueafteraerobictraining AT zahrahoseini myogenicdifferentiationmarkersinmuscletissueafteraerobictraining AT ayobkamangar myogenicdifferentiationmarkersinmuscletissueafteraerobictraining |