Altered cortical network dynamics during observing and preparing action in patients with corticobasal syndrome
Corticobasal syndrome (CBS) is characterized not only by parkinsonism but also by higher-order cortical dysfunctions, such as apraxia. However, the electrophysiological mechanisms underlying these symptoms remain poorly understood.To explore the pathophysiology of CBS, we recorded magnetoencephalogr...
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Elsevier
2025-02-01
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| Series: | Neurobiology of Disease |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996125000129 |
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| author | Marius Krösche Christian J. Hartmann Markus Butz Alfons Schnitzler Jan Hirschmann |
| author_facet | Marius Krösche Christian J. Hartmann Markus Butz Alfons Schnitzler Jan Hirschmann |
| author_sort | Marius Krösche |
| collection | DOAJ |
| description | Corticobasal syndrome (CBS) is characterized not only by parkinsonism but also by higher-order cortical dysfunctions, such as apraxia. However, the electrophysiological mechanisms underlying these symptoms remain poorly understood.To explore the pathophysiology of CBS, we recorded magnetoencephalographic (MEG) data from 17 CBS patients and 20 age-matched controls during an observe-to-imitate task. This task involved observing a tool-use video (action observation), withholding movement upon a Go cue (movement preparation), and subsequently imitating the tool-use action. We analyzed spectral power modulations at the source level.During action observation, event-related beta power (13-30 Hz) suppression was weaker in CBS patients compared to controls. This reduction was evident bilaterally in superior parietal, primary motor, premotor and inferior frontal cortex. During movement preparation, beta power suppression was also reduced in CBS patients, correlating with longer reaction times. Immediately prior to movement onset, however, beta suppression was comparable between groups.Our findings suggest that action observation induces beta suppression, likely indicative of motor cortical disinhibition, which is impaired in CBS patients. This alteration may represent a neural correlate of disrupted visuo-motor mapping in CBS. The altered timing of beta suppression to the Go cue suggests deficits in learning the task's temporal structure rather than in movement initiation itself. |
| format | Article |
| id | doaj-art-3d3c6039111545cf84347b5a8a6ea544 |
| institution | Kabale University |
| issn | 1095-953X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj-art-3d3c6039111545cf84347b5a8a6ea5442025-01-24T04:44:42ZengElsevierNeurobiology of Disease1095-953X2025-02-01205106796Altered cortical network dynamics during observing and preparing action in patients with corticobasal syndromeMarius Krösche0Christian J. Hartmann1Markus Butz2Alfons Schnitzler3Jan Hirschmann4Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, GermanyInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany; Center for Movement Disorders and Neuromodulation, Department of Neurology, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, GermanyInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, GermanyInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany; Center for Movement Disorders and Neuromodulation, Department of Neurology, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, GermanyInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany; Corresponding author at: Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, Moorenstraße 5, 40225 Düsseldorf, Germany.Corticobasal syndrome (CBS) is characterized not only by parkinsonism but also by higher-order cortical dysfunctions, such as apraxia. However, the electrophysiological mechanisms underlying these symptoms remain poorly understood.To explore the pathophysiology of CBS, we recorded magnetoencephalographic (MEG) data from 17 CBS patients and 20 age-matched controls during an observe-to-imitate task. This task involved observing a tool-use video (action observation), withholding movement upon a Go cue (movement preparation), and subsequently imitating the tool-use action. We analyzed spectral power modulations at the source level.During action observation, event-related beta power (13-30 Hz) suppression was weaker in CBS patients compared to controls. This reduction was evident bilaterally in superior parietal, primary motor, premotor and inferior frontal cortex. During movement preparation, beta power suppression was also reduced in CBS patients, correlating with longer reaction times. Immediately prior to movement onset, however, beta suppression was comparable between groups.Our findings suggest that action observation induces beta suppression, likely indicative of motor cortical disinhibition, which is impaired in CBS patients. This alteration may represent a neural correlate of disrupted visuo-motor mapping in CBS. The altered timing of beta suppression to the Go cue suggests deficits in learning the task's temporal structure rather than in movement initiation itself.http://www.sciencedirect.com/science/article/pii/S0969996125000129Corticobasal syndromeMagnetoencephalographyAction observationMovement preparationImitationBeta oscillations |
| spellingShingle | Marius Krösche Christian J. Hartmann Markus Butz Alfons Schnitzler Jan Hirschmann Altered cortical network dynamics during observing and preparing action in patients with corticobasal syndrome Neurobiology of Disease Corticobasal syndrome Magnetoencephalography Action observation Movement preparation Imitation Beta oscillations |
| title | Altered cortical network dynamics during observing and preparing action in patients with corticobasal syndrome |
| title_full | Altered cortical network dynamics during observing and preparing action in patients with corticobasal syndrome |
| title_fullStr | Altered cortical network dynamics during observing and preparing action in patients with corticobasal syndrome |
| title_full_unstemmed | Altered cortical network dynamics during observing and preparing action in patients with corticobasal syndrome |
| title_short | Altered cortical network dynamics during observing and preparing action in patients with corticobasal syndrome |
| title_sort | altered cortical network dynamics during observing and preparing action in patients with corticobasal syndrome |
| topic | Corticobasal syndrome Magnetoencephalography Action observation Movement preparation Imitation Beta oscillations |
| url | http://www.sciencedirect.com/science/article/pii/S0969996125000129 |
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