Clinicopathological importance of immunohistochemical expression of OCT4, c-MYC and Ki-67 in colorectal cancer
Cancer stem cells (CSCs) are cancer cells responsible for cancer initiation, growth, metastasis, recurrence and resistance to treatment. OCT4 and c-MYC are widely accepted as CSC markers. In this study, we examined the immunohistochemical co-expression of c-MYC and OCT4 with Ki-67 in colorectal can...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2024-12-01
|
| Series: | Polish Journal of Pathology |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Clinicopathological-importance-of-immunohistochemical-expression-of-OCT4-c-MYC-and-Ki-67-in-colorectal-cancer,55,55431,1,1.html |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832584715577589760 |
|---|---|
| author | Rabia Hursitoglu Abdulkadir Yasir Bahar Sezen Koçarslan Gökmen Aktaş Neslihan Kurtul Emine Kılınç |
| author_facet | Rabia Hursitoglu Abdulkadir Yasir Bahar Sezen Koçarslan Gökmen Aktaş Neslihan Kurtul Emine Kılınç |
| author_sort | Rabia Hursitoglu |
| collection | DOAJ |
| description | Cancer stem cells (CSCs) are cancer cells responsible for cancer initiation, growth, metastasis, recurrence and resistance to treatment. OCT4 and c-MYC are widely accepted as CSC markers.
In this study, we examined the immunohistochemical co-expression of c-MYC and OCT4 with Ki-67 in colorectal cancers (CRC) and the relationship between the results and prognostic and therapeutic data. c-MYC, OCT4 and Ki67 immunohistochemical staining was applied to 162 colectomy cases. Nuclear staining was considered for immunohistochemical staining. Survival in the c-MYC H /OCT4 H subtype, which is one of the subtypes based on c-MYC and OCT4 co-expression, was different from the other subtypes and statistically significant. Although these markers are enriched in cancer stem cells, their specificity in identifying them is limited. CSCs become dormant in the cell cycle, which is one of the mechanisms of escape in drug resistance. We hypothesized that including Ki67 immunohistochemical staining in our study would increase the specificity in detecting CSCs.
Our results show that the Ki67 L /c-MYC H /OCT4 H subgroup was associated with lower survival and resistance to treatment compared to the other subgroups. This finding may provide insight into cases with a high number of CSCs and guide targeted treatments. |
| format | Article |
| id | doaj-art-3d3a6aa702104dbc9d2dd8fbe792ecd2 |
| institution | Kabale University |
| issn | 1233-9687 2084-9869 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Polish Journal of Pathology |
| spelling | doaj-art-3d3a6aa702104dbc9d2dd8fbe792ecd22025-01-27T11:36:31ZengTermedia Publishing HousePolish Journal of Pathology1233-96872084-98692024-12-0175433334210.5114/pjp.2024.14646355431Clinicopathological importance of immunohistochemical expression of OCT4, c-MYC and Ki-67 in colorectal cancerRabia HursitogluAbdulkadir Yasir BaharSezen KoçarslanGökmen AktaşNeslihan KurtulEmine KılınçCancer stem cells (CSCs) are cancer cells responsible for cancer initiation, growth, metastasis, recurrence and resistance to treatment. OCT4 and c-MYC are widely accepted as CSC markers. In this study, we examined the immunohistochemical co-expression of c-MYC and OCT4 with Ki-67 in colorectal cancers (CRC) and the relationship between the results and prognostic and therapeutic data. c-MYC, OCT4 and Ki67 immunohistochemical staining was applied to 162 colectomy cases. Nuclear staining was considered for immunohistochemical staining. Survival in the c-MYC H /OCT4 H subtype, which is one of the subtypes based on c-MYC and OCT4 co-expression, was different from the other subtypes and statistically significant. Although these markers are enriched in cancer stem cells, their specificity in identifying them is limited. CSCs become dormant in the cell cycle, which is one of the mechanisms of escape in drug resistance. We hypothesized that including Ki67 immunohistochemical staining in our study would increase the specificity in detecting CSCs. Our results show that the Ki67 L /c-MYC H /OCT4 H subgroup was associated with lower survival and resistance to treatment compared to the other subgroups. This finding may provide insight into cases with a high number of CSCs and guide targeted treatments.https://www.termedia.pl/Clinicopathological-importance-of-immunohistochemical-expression-of-OCT4-c-MYC-and-Ki-67-in-colorectal-cancer,55,55431,1,1.htmlcolorectal cancer c-myc immunohistochemistry ki67 prognosis therapy |
| spellingShingle | Rabia Hursitoglu Abdulkadir Yasir Bahar Sezen Koçarslan Gökmen Aktaş Neslihan Kurtul Emine Kılınç Clinicopathological importance of immunohistochemical expression of OCT4, c-MYC and Ki-67 in colorectal cancer Polish Journal of Pathology colorectal cancer c-myc immunohistochemistry ki67 prognosis therapy |
| title | Clinicopathological importance of immunohistochemical expression of OCT4, c-MYC and Ki-67 in colorectal cancer |
| title_full | Clinicopathological importance of immunohistochemical expression of OCT4, c-MYC and Ki-67 in colorectal cancer |
| title_fullStr | Clinicopathological importance of immunohistochemical expression of OCT4, c-MYC and Ki-67 in colorectal cancer |
| title_full_unstemmed | Clinicopathological importance of immunohistochemical expression of OCT4, c-MYC and Ki-67 in colorectal cancer |
| title_short | Clinicopathological importance of immunohistochemical expression of OCT4, c-MYC and Ki-67 in colorectal cancer |
| title_sort | clinicopathological importance of immunohistochemical expression of oct4 c myc and ki 67 in colorectal cancer |
| topic | colorectal cancer c-myc immunohistochemistry ki67 prognosis therapy |
| url | https://www.termedia.pl/Clinicopathological-importance-of-immunohistochemical-expression-of-OCT4-c-MYC-and-Ki-67-in-colorectal-cancer,55,55431,1,1.html |
| work_keys_str_mv | AT rabiahursitoglu clinicopathologicalimportanceofimmunohistochemicalexpressionofoct4cmycandki67incolorectalcancer AT abdulkadiryasirbahar clinicopathologicalimportanceofimmunohistochemicalexpressionofoct4cmycandki67incolorectalcancer AT sezenkocarslan clinicopathologicalimportanceofimmunohistochemicalexpressionofoct4cmycandki67incolorectalcancer AT gokmenaktas clinicopathologicalimportanceofimmunohistochemicalexpressionofoct4cmycandki67incolorectalcancer AT neslihankurtul clinicopathologicalimportanceofimmunohistochemicalexpressionofoct4cmycandki67incolorectalcancer AT eminekılınc clinicopathologicalimportanceofimmunohistochemicalexpressionofoct4cmycandki67incolorectalcancer |