Resolution of Inflammation in Neurodegenerative Diseases: The Role of Resolvins
Acute inflammation has been described as a reactive dynamic process, promoted by the secretion of proinflammatory mediators, including lipid molecules like leukotrienes and prostaglandins, and counterbalanced by proresolving mediators including omega-3 polyunsaturated fatty-acid- (PUFA-) derived mol...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/3267172 |
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| _version_ | 1832547072007471104 |
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| author | Sajad Chamani Vanessa Bianconi Aida Tasbandi Matteo Pirro George E. Barreto Tannaz Jamialahmadi Amirhossein Sahebkar |
| author_facet | Sajad Chamani Vanessa Bianconi Aida Tasbandi Matteo Pirro George E. Barreto Tannaz Jamialahmadi Amirhossein Sahebkar |
| author_sort | Sajad Chamani |
| collection | DOAJ |
| description | Acute inflammation has been described as a reactive dynamic process, promoted by the secretion of proinflammatory mediators, including lipid molecules like leukotrienes and prostaglandins, and counterbalanced by proresolving mediators including omega-3 polyunsaturated fatty-acid- (PUFA-) derived molecules. The switch from the initiation to the resolution phase of acute inflammatory response is crucial for tissue homeostasis, whereas the failure to resolve early inflammation by specialized proresolving mediators leads to chronic inflammation and tissue damage. Among PUFA-derived proresolving mediators, different eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) derivatives have been described, namely, resolvins (resolution phase interaction products), which exert their anti-inflammatory and immune-regulatory activities through specific G-protein-coupled receptors. In recent years, compelling evidence has shown that impairment of resolution of inflammation is a crucial pathogenic hallmark in different neurodegenerative disorders, including Alzheimer’s disease and Parkinson’s disease. This review summarizes current knowledge on the role of resolvins in resolution of inflammation and highlights available evidence showing the neuroprotective potential of EPA- and DHA-derived resolvins (E-series and D-series resolvins, respectively) in neurodegenerative diseases. |
| format | Article |
| id | doaj-art-3d386c062d6f4970a16bc42de641aa25 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3d386c062d6f4970a16bc42de641aa252025-02-03T06:46:08ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/32671723267172Resolution of Inflammation in Neurodegenerative Diseases: The Role of ResolvinsSajad Chamani0Vanessa Bianconi1Aida Tasbandi2Matteo Pirro3George E. Barreto4Tannaz Jamialahmadi5Amirhossein Sahebkar6Birjand University of Medical Sciences, Birjand, IranUnit of Internal Medicine, Department of Medicine, University of Perugia, Perugia, ItalySchool of Medicine, Mashhad University of Medical Sciences, Mashhad, IranUnit of Internal Medicine, Department of Medicine, University of Perugia, Perugia, ItalyDepartment of Biological Sciences, University of Limerick, Limerick, IrelandBiotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, IranHalal Research Center of IRI, FDA, Tehran, IranAcute inflammation has been described as a reactive dynamic process, promoted by the secretion of proinflammatory mediators, including lipid molecules like leukotrienes and prostaglandins, and counterbalanced by proresolving mediators including omega-3 polyunsaturated fatty-acid- (PUFA-) derived molecules. The switch from the initiation to the resolution phase of acute inflammatory response is crucial for tissue homeostasis, whereas the failure to resolve early inflammation by specialized proresolving mediators leads to chronic inflammation and tissue damage. Among PUFA-derived proresolving mediators, different eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) derivatives have been described, namely, resolvins (resolution phase interaction products), which exert their anti-inflammatory and immune-regulatory activities through specific G-protein-coupled receptors. In recent years, compelling evidence has shown that impairment of resolution of inflammation is a crucial pathogenic hallmark in different neurodegenerative disorders, including Alzheimer’s disease and Parkinson’s disease. This review summarizes current knowledge on the role of resolvins in resolution of inflammation and highlights available evidence showing the neuroprotective potential of EPA- and DHA-derived resolvins (E-series and D-series resolvins, respectively) in neurodegenerative diseases.http://dx.doi.org/10.1155/2020/3267172 |
| spellingShingle | Sajad Chamani Vanessa Bianconi Aida Tasbandi Matteo Pirro George E. Barreto Tannaz Jamialahmadi Amirhossein Sahebkar Resolution of Inflammation in Neurodegenerative Diseases: The Role of Resolvins Mediators of Inflammation |
| title | Resolution of Inflammation in Neurodegenerative Diseases: The Role of Resolvins |
| title_full | Resolution of Inflammation in Neurodegenerative Diseases: The Role of Resolvins |
| title_fullStr | Resolution of Inflammation in Neurodegenerative Diseases: The Role of Resolvins |
| title_full_unstemmed | Resolution of Inflammation in Neurodegenerative Diseases: The Role of Resolvins |
| title_short | Resolution of Inflammation in Neurodegenerative Diseases: The Role of Resolvins |
| title_sort | resolution of inflammation in neurodegenerative diseases the role of resolvins |
| url | http://dx.doi.org/10.1155/2020/3267172 |
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