A real-world study of palbociclib plus endocrine therapy with or without a short course chemotherapy in the first-line treatment of HR-positive HER2-negative metastatic breast cancer

A real-world study of palbociclib plus endocrine therapy with or without a short course chemotherapy in the first-line treatment of HR-positive HER2-negative metastatic breast cancer

BackgroundTo investigate the efficacy of palbociclib plus endocrine therapy (ET) as the initial treatment compared with post-chemotherapy maintenance therapy in the first-line treatment of hormone receptor-positive (HR-positive), human epidermal growth factor receptor 2-negative (HER2-negative) meta...

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Bibliographic Details
Main Authors: Xiangjun Li, Yuhua Song, Meng Lv, Yongmei Wang, Xueqiang Gao, Tianyi Ma, Teng Ma, Changgen Liu, Xinyi Sun, Haibo Wang, Yan Mao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Oncology
Subjects:
metastatic breast cancer
palbociclib
endocrine treatment
cyclin-dependent kinases 4/6 inhibitor
chemotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1512496/full
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