Dual Immunotherapy for Pericardial Mesothelioma That Developed After a Decade‐Long Idiopathic Pericarditis: A Case Report
ABSTRACT Malignant pericardial mesothelioma (MPeM) is exceptionally rare, and its association with long‐standing idiopathic pericarditis remains unreported. We present a 46‐year‐old woman with a decade‐long history of recurrent idiopathic pericarditis who developed multiple pericardial nodules, medi...
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| Format: | Article |
| Language: | English |
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Wiley
2025-05-01
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| Series: | Respirology Case Reports |
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| Online Access: | https://doi.org/10.1002/rcr2.70190 |
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| author | Beatriz Grau Mirete Paula Rodriguez Paya Mariano Martinez Marin Asia Ferrández Arias Miguel Borregón Rivilla Antonio David Lazaro Sanchez Pedro Morillas Blasco Alvaro Rodriguez‐Lescure Javier David Benítez Fuentes |
| author_facet | Beatriz Grau Mirete Paula Rodriguez Paya Mariano Martinez Marin Asia Ferrández Arias Miguel Borregón Rivilla Antonio David Lazaro Sanchez Pedro Morillas Blasco Alvaro Rodriguez‐Lescure Javier David Benítez Fuentes |
| author_sort | Beatriz Grau Mirete |
| collection | DOAJ |
| description | ABSTRACT Malignant pericardial mesothelioma (MPeM) is exceptionally rare, and its association with long‐standing idiopathic pericarditis remains unreported. We present a 46‐year‐old woman with a decade‐long history of recurrent idiopathic pericarditis who developed multiple pericardial nodules, mediastinal lymphadenopathy, and metastatic liver and bone lesions. A core needle biopsy confirmed biphasic MPeM. Due to her pericardial condition, she initially received platinum‐based chemotherapy instead of immunotherapy, but the disease progressed. She then underwent dual immune checkpoint inhibition (ICI) and achieved a significant clinical and radiological response. This case raises the possibility of chronic inflammation contributing to pericardial malignancy and underscores the potential role of dual ICI in this rare and challenging disease. |
| format | Article |
| id | doaj-art-3d30ad09f39a435ba5e4c75bc3b3ab3f |
| institution | DOAJ |
| issn | 2051-3380 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Respirology Case Reports |
| spelling | doaj-art-3d30ad09f39a435ba5e4c75bc3b3ab3f2025-08-20T03:05:22ZengWileyRespirology Case Reports2051-33802025-05-01135n/an/a10.1002/rcr2.70190Dual Immunotherapy for Pericardial Mesothelioma That Developed After a Decade‐Long Idiopathic Pericarditis: A Case ReportBeatriz Grau Mirete0Paula Rodriguez Paya1Mariano Martinez Marin2Asia Ferrández Arias3Miguel Borregón Rivilla4Antonio David Lazaro Sanchez5Pedro Morillas Blasco6Alvaro Rodriguez‐Lescure7Javier David Benítez Fuentes8Department of Medical Oncology Hospital General Universitario de Elche, FISABIO Elche SpainDepartment of Medical Oncology Hospital General Universitario de Elche, FISABIO Elche SpainDepartment of Medical Oncology Hospital General Universitario de Elche, FISABIO Elche SpainDepartment of Medical Oncology Hospital General Universitario de Elche, FISABIO Elche SpainDepartment of Medical Oncology Hospital General Universitario de Elche, FISABIO Elche SpainDepartment of Medical Oncology Hospital General Universitario Morales Meseguer Murcia SpainDepartment of Cardiology Hospital General Universitario de Elche Elche SpainDepartment of Medical Oncology Hospital General Universitario de Elche, FISABIO Elche SpainDepartment of Medical Oncology Hospital General Universitario de Elche, FISABIO Elche SpainABSTRACT Malignant pericardial mesothelioma (MPeM) is exceptionally rare, and its association with long‐standing idiopathic pericarditis remains unreported. We present a 46‐year‐old woman with a decade‐long history of recurrent idiopathic pericarditis who developed multiple pericardial nodules, mediastinal lymphadenopathy, and metastatic liver and bone lesions. A core needle biopsy confirmed biphasic MPeM. Due to her pericardial condition, she initially received platinum‐based chemotherapy instead of immunotherapy, but the disease progressed. She then underwent dual immune checkpoint inhibition (ICI) and achieved a significant clinical and radiological response. This case raises the possibility of chronic inflammation contributing to pericardial malignancy and underscores the potential role of dual ICI in this rare and challenging disease.https://doi.org/10.1002/rcr2.70190case reportdual immunotherapyidiopathic pericarditisimmune checkpointpericardial mesothelioma |
| spellingShingle | Beatriz Grau Mirete Paula Rodriguez Paya Mariano Martinez Marin Asia Ferrández Arias Miguel Borregón Rivilla Antonio David Lazaro Sanchez Pedro Morillas Blasco Alvaro Rodriguez‐Lescure Javier David Benítez Fuentes Dual Immunotherapy for Pericardial Mesothelioma That Developed After a Decade‐Long Idiopathic Pericarditis: A Case Report Respirology Case Reports case report dual immunotherapy idiopathic pericarditis immune checkpoint pericardial mesothelioma |
| title | Dual Immunotherapy for Pericardial Mesothelioma That Developed After a Decade‐Long Idiopathic Pericarditis: A Case Report |
| title_full | Dual Immunotherapy for Pericardial Mesothelioma That Developed After a Decade‐Long Idiopathic Pericarditis: A Case Report |
| title_fullStr | Dual Immunotherapy for Pericardial Mesothelioma That Developed After a Decade‐Long Idiopathic Pericarditis: A Case Report |
| title_full_unstemmed | Dual Immunotherapy for Pericardial Mesothelioma That Developed After a Decade‐Long Idiopathic Pericarditis: A Case Report |
| title_short | Dual Immunotherapy for Pericardial Mesothelioma That Developed After a Decade‐Long Idiopathic Pericarditis: A Case Report |
| title_sort | dual immunotherapy for pericardial mesothelioma that developed after a decade long idiopathic pericarditis a case report |
| topic | case report dual immunotherapy idiopathic pericarditis immune checkpoint pericardial mesothelioma |
| url | https://doi.org/10.1002/rcr2.70190 |
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