Angiotensin Receptor–Neprilysin Inhibition (Sacubitril/Valsartan) Reduces Structural Arterial Stiffness in Middle‐Aged Mice

Angiotensin Receptor–Neprilysin Inhibition (Sacubitril/Valsartan) Reduces Structural Arterial Stiffness in Middle‐Aged Mice

Background Increasing arterial stiffness is a prominent feature of the aging cardiovascular system. Arterial stiffening leads to fundamental alterations in central hemodynamics with widespread detrimental implications for organ function resulting in significant morbidity and death, and specific ther...

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Main Authors: Isabel N. Schellinger, Angelika Dannert, Annet Hoffmann, Giriprakash Chodisetti, Karin Mattern, Anne Petzold, Nora Klöting, Andreas Schuster, Markus U. Wagenhäuser, Fabian Emrich, Michael Stumvoll, Gerd Hasenfuß, Uwe Raaz
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
aging
angiotensin receptor antagonists
fibrosis
mice
neprilysin
pulse wave analysis
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.123.032641
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