Systemic and Local CC Chemokines Production in a Murine Model of <emph>Listeria monocytogenes</emph> Infection
<p>Repeated intragastric inoculation of <emph>Listeria monocytogenes</emph> into BALB/c mice resulted in prolonged bacteraemia and severe hepatic infection. Bacteria could also be isolated from the brain tissue of all experimental mice. During the inflammatory process, chemokine co...
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| Language: | English |
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Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://www.hindawi.com/GetArticle.aspx?doi=10.1155/MI/2006/54202 |
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| description | <p>Repeated intragastric inoculation of <emph>Listeria monocytogenes</emph> into BALB/c mice resulted in prolonged bacteraemia and severe hepatic infection. Bacteria could also be isolated from the brain tissue of all experimental mice. During the inflammatory process, chemokine concentrations typically increased at the local site in comparison to the systemic level. The liver-to-serum ratio was more pronounced in the case of macrophage inflammatory protein 1<mml:math> <mml:mi>α</mml:mi> </mml:math> (MIP-1<mml:math> <mml:mi>α</mml:mi> </mml:math> ), suggesting its role in the inflammatory response in the liver. The ratio of brain-to-serum concentration of monocyte chemoattractant protein 1 (MCP-1) remained the same as in the control animals, while it was lower in the infected mice, both in the case MIP-1<mml:math> <mml:mi>α</mml:mi> </mml:math> and in the case of regulated on activation, normal T cell expressed and secreted (RANTES). This is in correlation with slight inflammatory infiltrates found in the brain tissue early in infection.</p> |
| format | Article |
| id | doaj-art-3d24ebc18aa6444a8fb5873f3b0400b8 |
| institution | Kabale University |
| issn | 0962-9351 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3d24ebc18aa6444a8fb5873f3b0400b82025-02-03T01:29:07ZengWileyMediators of Inflammation0962-93512006-01-012006Systemic and Local CC Chemokines Production in a Murine Model of <emph>Listeria monocytogenes</emph> Infection<p>Repeated intragastric inoculation of <emph>Listeria monocytogenes</emph> into BALB/c mice resulted in prolonged bacteraemia and severe hepatic infection. Bacteria could also be isolated from the brain tissue of all experimental mice. During the inflammatory process, chemokine concentrations typically increased at the local site in comparison to the systemic level. The liver-to-serum ratio was more pronounced in the case of macrophage inflammatory protein 1<mml:math> <mml:mi>α</mml:mi> </mml:math> (MIP-1<mml:math> <mml:mi>α</mml:mi> </mml:math> ), suggesting its role in the inflammatory response in the liver. The ratio of brain-to-serum concentration of monocyte chemoattractant protein 1 (MCP-1) remained the same as in the control animals, while it was lower in the infected mice, both in the case MIP-1<mml:math> <mml:mi>α</mml:mi> </mml:math> and in the case of regulated on activation, normal T cell expressed and secreted (RANTES). This is in correlation with slight inflammatory infiltrates found in the brain tissue early in infection.</p>http://www.hindawi.com/GetArticle.aspx?doi=10.1155/MI/2006/54202 |
| spellingShingle | Systemic and Local CC Chemokines Production in a Murine Model of <emph>Listeria monocytogenes</emph> Infection Mediators of Inflammation |
| title | Systemic and Local CC Chemokines Production in a Murine Model of <emph>Listeria monocytogenes</emph> Infection |
| title_full | Systemic and Local CC Chemokines Production in a Murine Model of <emph>Listeria monocytogenes</emph> Infection |
| title_fullStr | Systemic and Local CC Chemokines Production in a Murine Model of <emph>Listeria monocytogenes</emph> Infection |
| title_full_unstemmed | Systemic and Local CC Chemokines Production in a Murine Model of <emph>Listeria monocytogenes</emph> Infection |
| title_short | Systemic and Local CC Chemokines Production in a Murine Model of <emph>Listeria monocytogenes</emph> Infection |
| title_sort | systemic and local cc chemokines production in a murine model of emph listeria monocytogenes emph infection |
| url | http://www.hindawi.com/GetArticle.aspx?doi=10.1155/MI/2006/54202 |