The in vitro anticancer effects of FS48 from salivary glands of Xenopsylla cheopis on NCI-H460 cells via its blockage of voltage-gated K+ channels

The in vitro anticancer effects of FS48 from salivary glands of Xenopsylla cheopis on NCI-H460 cells via its blockage of voltage-gated K+ channels

Voltage-gated K+ (Kv) channels play a role in the cellular processes of various cancer cells, including lung cancer cells. We previously identified and reported a salivary protein from the Xenopsylla cheopis, FS48, which exhibited inhibitory activity against Kv1.1-1.3 channels when assayed in HEK 29...

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Bibliographic Details
Main Authors: Xiong Weichen, Fan Huizhen, Zeng Qingye, Deng Zhenhui, Li Guanhui, Lu Wancheng, Zhang Bei, Lai Shian, Chen Xin, Xu Xueqing
Format: Article
Language:English
Published: Sciendo 2023-03-01
Series:Acta Pharmaceutica
Subjects:
lung cancer
kv channels
fs48
nci-h460 cells
anticancer
Online Access:https://doi.org/10.2478/acph-2023-0010
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Internet

https://doi.org/10.2478/acph-2023-0010

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