The Metabolic Syndrome and Biochemical Recurrence following Radical Prostatectomy
Metabolic syndrome refers to a set of conditions that increases the risk of cardiovascular disease and has been associated with an increased risk of prostate cancer, particularly among African American men. This study aimed to estimate the association of metabolic syndrome with biochemical recurrenc...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2011/245642 |
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| _version_ | 1832548670448336896 |
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| author | Jennifer M. Post Jennifer L. Beebe-Dimmer Hal Morgenstern Christine Neslund-Dudas Cathryn H. Bock Nora Nock Andrew Rundle Michelle Jankowski Benjamin A. Rybicki |
| author_facet | Jennifer M. Post Jennifer L. Beebe-Dimmer Hal Morgenstern Christine Neslund-Dudas Cathryn H. Bock Nora Nock Andrew Rundle Michelle Jankowski Benjamin A. Rybicki |
| author_sort | Jennifer M. Post |
| collection | DOAJ |
| description | Metabolic syndrome refers to a set of conditions that increases the risk of cardiovascular disease and has been associated with an increased risk of prostate cancer, particularly among African American men. This study aimed to estimate the association of metabolic syndrome with biochemical recurrence (BCR) in a racially diverse population. Among 383 radical prostatectomy patients, 67 patients had documented biochemical recurrence. Hypertension was significantly, positively associated with the rate of BCR (hazard ratio (HR) = 2.1; 95% CI = 1.1, 3.8). There were distinct racial differences in the prevalence of individual metabolic syndrome components; however, the observed associations with BCR did not differ appreciably by race. We conclude that hypertension may contribute to a poorer prognosis in surgically treated prostate cancer patients. Our findings suggest that targeting components of the metabolic syndrome which are potentially modifiable through lifestyle interventions may be a viable strategy to reduce risk of BCR in prostate cancer. |
| format | Article |
| id | doaj-art-3d108288beb642f18ba29da15ab39af0 |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-3d108288beb642f18ba29da15ab39af02025-02-03T06:13:21ZengWileyProstate Cancer2090-31112090-312X2011-01-01201110.1155/2011/245642245642The Metabolic Syndrome and Biochemical Recurrence following Radical ProstatectomyJennifer M. Post0Jennifer L. Beebe-Dimmer1Hal Morgenstern2Christine Neslund-Dudas3Cathryn H. Bock4Nora Nock5Andrew Rundle6Michelle Jankowski7Benjamin A. Rybicki8Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USAKarmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USADepartments of Epidemiology and Environmental Health Sciences and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48103, USADepartment of Biostatistics and Research Epidemiology, Henry Ford Hospital, Detroit, MI 48310, USAKarmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USADepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44109, USADepartments of Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USADepartment of Biostatistics and Research Epidemiology, Henry Ford Hospital, Detroit, MI 48310, USAKarmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USAMetabolic syndrome refers to a set of conditions that increases the risk of cardiovascular disease and has been associated with an increased risk of prostate cancer, particularly among African American men. This study aimed to estimate the association of metabolic syndrome with biochemical recurrence (BCR) in a racially diverse population. Among 383 radical prostatectomy patients, 67 patients had documented biochemical recurrence. Hypertension was significantly, positively associated with the rate of BCR (hazard ratio (HR) = 2.1; 95% CI = 1.1, 3.8). There were distinct racial differences in the prevalence of individual metabolic syndrome components; however, the observed associations with BCR did not differ appreciably by race. We conclude that hypertension may contribute to a poorer prognosis in surgically treated prostate cancer patients. Our findings suggest that targeting components of the metabolic syndrome which are potentially modifiable through lifestyle interventions may be a viable strategy to reduce risk of BCR in prostate cancer.http://dx.doi.org/10.1155/2011/245642 |
| spellingShingle | Jennifer M. Post Jennifer L. Beebe-Dimmer Hal Morgenstern Christine Neslund-Dudas Cathryn H. Bock Nora Nock Andrew Rundle Michelle Jankowski Benjamin A. Rybicki The Metabolic Syndrome and Biochemical Recurrence following Radical Prostatectomy Prostate Cancer |
| title | The Metabolic Syndrome and Biochemical Recurrence following Radical Prostatectomy |
| title_full | The Metabolic Syndrome and Biochemical Recurrence following Radical Prostatectomy |
| title_fullStr | The Metabolic Syndrome and Biochemical Recurrence following Radical Prostatectomy |
| title_full_unstemmed | The Metabolic Syndrome and Biochemical Recurrence following Radical Prostatectomy |
| title_short | The Metabolic Syndrome and Biochemical Recurrence following Radical Prostatectomy |
| title_sort | metabolic syndrome and biochemical recurrence following radical prostatectomy |
| url | http://dx.doi.org/10.1155/2011/245642 |
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