Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal Neurogenesis
Microglia cells are the major orchestrator of the brain inflammatory response. As such, they are traditionally studied in various contexts of trauma, injury, and disease, where they are well-known for regulating a wide range of physiological processes by their release of proinflammatory cytokines, r...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2014/610343 |
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| author | Amanda Sierra Sol Beccari Irune Diaz-Aparicio Juan M. Encinas Samuel Comeau Marie-Ève Tremblay |
| author_facet | Amanda Sierra Sol Beccari Irune Diaz-Aparicio Juan M. Encinas Samuel Comeau Marie-Ève Tremblay |
| author_sort | Amanda Sierra |
| collection | DOAJ |
| description | Microglia cells are the major orchestrator of the brain inflammatory response. As such, they are traditionally studied in various contexts of trauma, injury, and disease, where they are well-known for regulating a wide range of physiological processes by their release of proinflammatory cytokines, reactive oxygen species, and trophic factors, among other crucial mediators. In the last few years, however, this classical view of microglia was challenged by a series of discoveries showing their active and positive contribution to normal brain functions. In light of these discoveries, surveillant microglia are now emerging as an important effector of cellular plasticity in the healthy brain, alongside astrocytes and other types of inflammatory cells. Here, we will review the roles of microglia in adult hippocampal neurogenesis and their regulation by inflammation during chronic stress, aging, and neurodegenerative diseases, with a particular emphasis on their underlying molecular mechanisms and their functional consequences for learning and memory. |
| format | Article |
| id | doaj-art-3d0c4fea95b94a8b90c711e6081e13eb |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-3d0c4fea95b94a8b90c711e6081e13eb2025-02-03T01:30:09ZengWileyNeural Plasticity2090-59041687-54432014-01-01201410.1155/2014/610343610343Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal NeurogenesisAmanda Sierra0Sol Beccari1Irune Diaz-Aparicio2Juan M. Encinas3Samuel Comeau4Marie-Ève Tremblay5Ikerbasque Foundation, 48011 Bilbao, SpainAchucarro Basque Center for Neuroscience, Bizkaia Science and Technology Park, 48170 Zamudio, SpainAchucarro Basque Center for Neuroscience, Bizkaia Science and Technology Park, 48170 Zamudio, SpainIkerbasque Foundation, 48011 Bilbao, SpainCentre de Recherche du CHU de Québec, Axe Neurosciences, G1P 4C7, CanadaCentre de Recherche du CHU de Québec, Axe Neurosciences, G1P 4C7, CanadaMicroglia cells are the major orchestrator of the brain inflammatory response. As such, they are traditionally studied in various contexts of trauma, injury, and disease, where they are well-known for regulating a wide range of physiological processes by their release of proinflammatory cytokines, reactive oxygen species, and trophic factors, among other crucial mediators. In the last few years, however, this classical view of microglia was challenged by a series of discoveries showing their active and positive contribution to normal brain functions. In light of these discoveries, surveillant microglia are now emerging as an important effector of cellular plasticity in the healthy brain, alongside astrocytes and other types of inflammatory cells. Here, we will review the roles of microglia in adult hippocampal neurogenesis and their regulation by inflammation during chronic stress, aging, and neurodegenerative diseases, with a particular emphasis on their underlying molecular mechanisms and their functional consequences for learning and memory.http://dx.doi.org/10.1155/2014/610343 |
| spellingShingle | Amanda Sierra Sol Beccari Irune Diaz-Aparicio Juan M. Encinas Samuel Comeau Marie-Ève Tremblay Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal Neurogenesis Neural Plasticity |
| title | Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal Neurogenesis |
| title_full | Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal Neurogenesis |
| title_fullStr | Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal Neurogenesis |
| title_full_unstemmed | Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal Neurogenesis |
| title_short | Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal Neurogenesis |
| title_sort | surveillance phagocytosis and inflammation how never resting microglia influence adult hippocampal neurogenesis |
| url | http://dx.doi.org/10.1155/2014/610343 |
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