Airway epithelial stem cell renewal and differentiation: overcoming challenging steps towards clinical-grade tissue engineering

Airway epithelial stem cell renewal and differentiation: overcoming challenging steps towards clinical-grade tissue engineering

Abstract Background Despite their life-saving potential, tissue engineering approaches for the treatment of extensive tracheal and bronchial defects still face significant limitations. A major challenge is the inability to regenerate a functional airway epithelium containing the appropriate amount o...

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Main Authors: Davide Adamo, Vincenzo Giuseppe Genna, Giulia Galaverni, Chiara Chiavelli, Alessia Merra, Fabio Lepore, Federica Boraldi, Daniela Quaglino, Jessica Evangelista, Filippo Lococo, Graziella Pellegrini
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Stem Cell Research & Therapy
Subjects:
Tracheobronchial epithelium
Epithelial stem cells
Airway holoclones
Regenerative medicine
Tissue engineering
Airway reconstruction
Online Access:https://doi.org/10.1186/s13287-025-04478-0
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