A Pilot Study Examining the Relationship among Crohn Disease Activity, Glucagon-Like Peptide-2 Signalling and Intestinal Function in Pediatric Patients
BACKGROUND/OBJECTIVES: The relationship between the enteroendocrine hormone glucagon-like peptide 2 (GLP-2) and intestinal inflammation is unclear. GLP-2 promotes mucosal growth, decreases permeability and reduces inflammation in the intestine; physiological stimulation of GLP-2 release is triggered...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2013/460958 |
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| _version_ | 1832558714542882816 |
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| author | David L Sigalet Dragan Kravarusic Decker Butzner Bolette Hartmann Jens J Holst Jon Meddings |
| author_facet | David L Sigalet Dragan Kravarusic Decker Butzner Bolette Hartmann Jens J Holst Jon Meddings |
| author_sort | David L Sigalet |
| collection | DOAJ |
| description | BACKGROUND/OBJECTIVES: The relationship between the enteroendocrine hormone glucagon-like peptide 2 (GLP-2) and intestinal inflammation is unclear. GLP-2 promotes mucosal growth, decreases permeability and reduces inflammation in the intestine; physiological stimulation of GLP-2 release is triggered by nutrient contact. The authors hypothesized that ileal Crohn disease (CD) affects GLP-2 release. |
| format | Article |
| id | doaj-art-3cf10f08455d4ad085ba5fa2772d477c |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-3cf10f08455d4ad085ba5fa2772d477c2025-02-03T01:31:40ZengWileyCanadian Journal of Gastroenterology0835-79002013-01-01271058759210.1155/2013/460958A Pilot Study Examining the Relationship among Crohn Disease Activity, Glucagon-Like Peptide-2 Signalling and Intestinal Function in Pediatric PatientsDavid L Sigalet0Dragan Kravarusic1Decker Butzner2Bolette Hartmann3Jens J Holst4Jon Meddings5Gastrointestinal Research Group, Snyder Institute of Infection, Immunity and Inflammation, Deparment of Surgery, Faculty of Medicine, University of Calgary, Calgary, Alberta, CanadaDeptartment of Surgery, University of Tel Aviv, Tel Aviv, IsraelGastrointestinal Research Group, Snyder Institute of Infection, Immunity and Inflammation, Deparment of Surgery, Faculty of Medicine, University of Calgary, Calgary, Alberta, CanadaPanum Institute, University of Copenhagen, Copenhagen, DenmarkPanum Institute, University of Copenhagen, Copenhagen, DenmarkGastrointestinal Research Group, Snyder Institute of Infection, Immunity and Inflammation, Deparment of Surgery, Faculty of Medicine, University of Calgary, Calgary, Alberta, CanadaBACKGROUND/OBJECTIVES: The relationship between the enteroendocrine hormone glucagon-like peptide 2 (GLP-2) and intestinal inflammation is unclear. GLP-2 promotes mucosal growth, decreases permeability and reduces inflammation in the intestine; physiological stimulation of GLP-2 release is triggered by nutrient contact. The authors hypothesized that ileal Crohn disease (CD) affects GLP-2 release.http://dx.doi.org/10.1155/2013/460958 |
| spellingShingle | David L Sigalet Dragan Kravarusic Decker Butzner Bolette Hartmann Jens J Holst Jon Meddings A Pilot Study Examining the Relationship among Crohn Disease Activity, Glucagon-Like Peptide-2 Signalling and Intestinal Function in Pediatric Patients Canadian Journal of Gastroenterology |
| title | A Pilot Study Examining the Relationship among Crohn Disease Activity, Glucagon-Like Peptide-2 Signalling and Intestinal Function in Pediatric Patients |
| title_full | A Pilot Study Examining the Relationship among Crohn Disease Activity, Glucagon-Like Peptide-2 Signalling and Intestinal Function in Pediatric Patients |
| title_fullStr | A Pilot Study Examining the Relationship among Crohn Disease Activity, Glucagon-Like Peptide-2 Signalling and Intestinal Function in Pediatric Patients |
| title_full_unstemmed | A Pilot Study Examining the Relationship among Crohn Disease Activity, Glucagon-Like Peptide-2 Signalling and Intestinal Function in Pediatric Patients |
| title_short | A Pilot Study Examining the Relationship among Crohn Disease Activity, Glucagon-Like Peptide-2 Signalling and Intestinal Function in Pediatric Patients |
| title_sort | pilot study examining the relationship among crohn disease activity glucagon like peptide 2 signalling and intestinal function in pediatric patients |
| url | http://dx.doi.org/10.1155/2013/460958 |
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