Region-specific hippocampal atrophy is correlated with poor glycemic control in type 2 diabetes: a cross-sectional study
To examine the association between prediabetes/type 2 diabetes mellitus (T2DM) and hippocampal subfields and to investigate the effects of glycemic control (HbA1c and FBG)/diabetes duration on the volume of hippocampal subfields in T2DM patients. This cross-sectional study included 268 participants...
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The Japan Endocrine Society
2023-12-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/70/12/70_EJ23-0211/_html/-char/en |
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| author | Cuiping Bao Xuehuan Liu Yiming Li Jun Yang Feng Wei Yi Gong Zhihui Ma Jun Liu |
| author_facet | Cuiping Bao Xuehuan Liu Yiming Li Jun Yang Feng Wei Yi Gong Zhihui Ma Jun Liu |
| author_sort | Cuiping Bao |
| collection | DOAJ |
| description | To examine the association between prediabetes/type 2 diabetes mellitus (T2DM) and hippocampal subfields and to investigate the effects of glycemic control (HbA1c and FBG)/diabetes duration on the volume of hippocampal subfields in T2DM patients. This cross-sectional study included 268 participants from Tianjin Union Medical Center between August 2019 and July 2022. The participants were divided into three groups: T2DM, prediabetes and no diabetes. All participants underwent brain MRI examination on a 3T MRI scanner. FreeSurfer was performed to segment hippocampus automatically based on T1 MPRAGE images. The relationships between glycemic status/glycemic control/diabetes duration and hippocampal subfield volumes were estimated by multiple linear regression analysis/generalized additive modeling (GAM). Among all participants, 76 (28.36%) had prediabetes, and 96 (35.82%) had T2DM. In multi-adjusted linear regression models, those with prediabetes had a significantly lower volume of bilateral parasubiculum (βright = –5.540; βleft = –6.497). Those with diabetes had lower volume of parasubiculum (βleft = –7.868), presubiculum-head (βleft = –6.244) and fimbria (βleft = –7.187). We did not find relationship between diabetes duration and hippocampal subfield volumes. In stratified analysis, long duration with high FBG related with lower volume of right fimbria (βright = –15.583). Long duration with high HbA1c related with lower volume of presubiculum-head (βright = –19.693), subiculum-head (βright = –28.303), subiculum-body (βleft = –38.599), CA1-head (βright = –62.300, βleft = –47.922), CA1-body (βright = –19.043), CA4-body (βright = –14.392), GC-ML-DG-head (βright = –20.521), GC-ML-DG-body (βright = –16.293, βleft = –12.799), molecular_layer_HP-head (βright = –44.202, βleft = –26.071) and molecular_layer_HP-body, (βright = –31.368), hippocampal_tail (βleft = –80.073). Prediabetes related with lower bilateral parasubiculum volume, and T2DM related with lower left parasubiculum, presubiculum-head and fimbria. T2DM with chronic poor glycemic control had lower volume in multiple hippocampal subregions. |
| format | Article |
| id | doaj-art-3cf0330616ca4f25b2d309787c0506ab |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | The Japan Endocrine Society |
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| series | Endocrine Journal |
| spelling | doaj-art-3cf0330616ca4f25b2d309787c0506ab2025-01-22T06:25:09ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402023-12-0170121131114010.1507/endocrj.EJ23-0211endocrjRegion-specific hippocampal atrophy is correlated with poor glycemic control in type 2 diabetes: a cross-sectional studyCuiping Bao0Xuehuan Liu1Yiming Li2Jun Yang3Feng Wei4Yi Gong5Zhihui Ma6Jun Liu7Department of Radiology, Tianjin Union Medical Center, Nankai University, Tianjin 300121, ChinaDepartment of Radiology, Tianjin Union Medical Center, Nankai University, Tianjin 300121, ChinaDepartment of Radiology, Tianjin Union Medical Center, Nankai University, Tianjin 300121, ChinaDepartment of Radiology, Tianjin Union Medical Center, Nankai University, Tianjin 300121, ChinaDepartment of Radiology, Tianjin Union Medical Center, Nankai University, Tianjin 300121, ChinaDepartment of Radiology, Tianjin Union Medical Center, Nankai University, Tianjin 300121, ChinaDepartment of Radiology, Tianjin Union Medical Center, Nankai University, Tianjin 300121, ChinaThe Fourth Central Clinical College, Tianjin Medical University, Tianjin 300140, ChinaTo examine the association between prediabetes/type 2 diabetes mellitus (T2DM) and hippocampal subfields and to investigate the effects of glycemic control (HbA1c and FBG)/diabetes duration on the volume of hippocampal subfields in T2DM patients. This cross-sectional study included 268 participants from Tianjin Union Medical Center between August 2019 and July 2022. The participants were divided into three groups: T2DM, prediabetes and no diabetes. All participants underwent brain MRI examination on a 3T MRI scanner. FreeSurfer was performed to segment hippocampus automatically based on T1 MPRAGE images. The relationships between glycemic status/glycemic control/diabetes duration and hippocampal subfield volumes were estimated by multiple linear regression analysis/generalized additive modeling (GAM). Among all participants, 76 (28.36%) had prediabetes, and 96 (35.82%) had T2DM. In multi-adjusted linear regression models, those with prediabetes had a significantly lower volume of bilateral parasubiculum (βright = –5.540; βleft = –6.497). Those with diabetes had lower volume of parasubiculum (βleft = –7.868), presubiculum-head (βleft = –6.244) and fimbria (βleft = –7.187). We did not find relationship between diabetes duration and hippocampal subfield volumes. In stratified analysis, long duration with high FBG related with lower volume of right fimbria (βright = –15.583). Long duration with high HbA1c related with lower volume of presubiculum-head (βright = –19.693), subiculum-head (βright = –28.303), subiculum-body (βleft = –38.599), CA1-head (βright = –62.300, βleft = –47.922), CA1-body (βright = –19.043), CA4-body (βright = –14.392), GC-ML-DG-head (βright = –20.521), GC-ML-DG-body (βright = –16.293, βleft = –12.799), molecular_layer_HP-head (βright = –44.202, βleft = –26.071) and molecular_layer_HP-body, (βright = –31.368), hippocampal_tail (βleft = –80.073). Prediabetes related with lower bilateral parasubiculum volume, and T2DM related with lower left parasubiculum, presubiculum-head and fimbria. T2DM with chronic poor glycemic control had lower volume in multiple hippocampal subregions.https://www.jstage.jst.go.jp/article/endocrj/70/12/70_EJ23-0211/_html/-char/entype 2 diabetes mellitus (t2dm)regional hippocampusglucose control |
| spellingShingle | Cuiping Bao Xuehuan Liu Yiming Li Jun Yang Feng Wei Yi Gong Zhihui Ma Jun Liu Region-specific hippocampal atrophy is correlated with poor glycemic control in type 2 diabetes: a cross-sectional study Endocrine Journal type 2 diabetes mellitus (t2dm) regional hippocampus glucose control |
| title | Region-specific hippocampal atrophy is correlated with poor glycemic control in type 2 diabetes: a cross-sectional study |
| title_full | Region-specific hippocampal atrophy is correlated with poor glycemic control in type 2 diabetes: a cross-sectional study |
| title_fullStr | Region-specific hippocampal atrophy is correlated with poor glycemic control in type 2 diabetes: a cross-sectional study |
| title_full_unstemmed | Region-specific hippocampal atrophy is correlated with poor glycemic control in type 2 diabetes: a cross-sectional study |
| title_short | Region-specific hippocampal atrophy is correlated with poor glycemic control in type 2 diabetes: a cross-sectional study |
| title_sort | region specific hippocampal atrophy is correlated with poor glycemic control in type 2 diabetes a cross sectional study |
| topic | type 2 diabetes mellitus (t2dm) regional hippocampus glucose control |
| url | https://www.jstage.jst.go.jp/article/endocrj/70/12/70_EJ23-0211/_html/-char/en |
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