Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis
Type 2 diabetes is the most prevalent and serious metabolic disease all over the world, and its hallmarks are pancreatic 𝛽-cell dysfunction and insulin resistance. Under diabetic conditions, chronic hyperglycemia and subsequent augmentation of reactive oxygen species (ROS) deteriorate 𝛽-cell functio...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/453892 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566939848802304 |
|---|---|
| author | Hideaki Kaneto Naoto Katakami Munehide Matsuhisa Taka-aki Matsuoka |
| author_facet | Hideaki Kaneto Naoto Katakami Munehide Matsuhisa Taka-aki Matsuoka |
| author_sort | Hideaki Kaneto |
| collection | DOAJ |
| description | Type 2 diabetes is the most prevalent and serious metabolic disease all over the world, and its hallmarks are pancreatic 𝛽-cell dysfunction and insulin resistance. Under diabetic conditions, chronic hyperglycemia and subsequent augmentation of reactive oxygen species (ROS) deteriorate 𝛽-cell function and increase insulin resistance which leads to the aggravation of type 2 diabetes. In addition, chronic hyperglycemia and ROS are also involved in the development of atherosclerosis which is often observed under diabetic conditions. Taken together, it is likely that ROS play an important role in the development of type 2 diabetes and atherosclerosis. |
| format | Article |
| id | doaj-art-3ce63c1606304bef99ba4b9c3e4f5e22 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3ce63c1606304bef99ba4b9c3e4f5e222025-02-03T01:02:41ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/453892453892Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and AtherosclerosisHideaki Kaneto0Naoto Katakami1Munehide Matsuhisa2Taka-aki Matsuoka3Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanType 2 diabetes is the most prevalent and serious metabolic disease all over the world, and its hallmarks are pancreatic 𝛽-cell dysfunction and insulin resistance. Under diabetic conditions, chronic hyperglycemia and subsequent augmentation of reactive oxygen species (ROS) deteriorate 𝛽-cell function and increase insulin resistance which leads to the aggravation of type 2 diabetes. In addition, chronic hyperglycemia and ROS are also involved in the development of atherosclerosis which is often observed under diabetic conditions. Taken together, it is likely that ROS play an important role in the development of type 2 diabetes and atherosclerosis.http://dx.doi.org/10.1155/2010/453892 |
| spellingShingle | Hideaki Kaneto Naoto Katakami Munehide Matsuhisa Taka-aki Matsuoka Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis Mediators of Inflammation |
| title | Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis |
| title_full | Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis |
| title_fullStr | Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis |
| title_full_unstemmed | Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis |
| title_short | Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis |
| title_sort | role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis |
| url | http://dx.doi.org/10.1155/2010/453892 |
| work_keys_str_mv | AT hideakikaneto roleofreactiveoxygenspeciesintheprogressionoftype2diabetesandatherosclerosis AT naotokatakami roleofreactiveoxygenspeciesintheprogressionoftype2diabetesandatherosclerosis AT munehidematsuhisa roleofreactiveoxygenspeciesintheprogressionoftype2diabetesandatherosclerosis AT takaakimatsuoka roleofreactiveoxygenspeciesintheprogressionoftype2diabetesandatherosclerosis |