Clinical Evolution of Central Pontine Myelinolysis in a Patient with Alcohol Withdrawal: A Blurred Clinical Horizon
Central pontine myelinolysis (CPM), a potentially fatal and debilitating neurological condition, was first described in 1959 in a study on alcoholic and malnourished patients. It is a condition most frequently related to rapid correction of hyponatremia. Chronic alcoholism associated CPM tends to be...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/6065259 |
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| author | Abdul S. Mohammed Prajwal Boddu Dina F. Yazdani |
| author_facet | Abdul S. Mohammed Prajwal Boddu Dina F. Yazdani |
| author_sort | Abdul S. Mohammed |
| collection | DOAJ |
| description | Central pontine myelinolysis (CPM), a potentially fatal and debilitating neurological condition, was first described in 1959 in a study on alcoholic and malnourished patients. It is a condition most frequently related to rapid correction of hyponatremia. Chronic alcoholism associated CPM tends to be benign with a favorable prognosis compared to CPM secondary to rapid correction of hyponatremia. We describe a normonatremic, alcoholic patient who presented with CPM after a rapid rise in his sodium levels. Our case illustrates the fact that CPM can manifest even in patients who are normonatremic at baseline. Rapid rises in sodium levels should be promptly reversed before clinical symptoms manifest in patient with risk factors for CPM irrespective of their baseline sodium levels. Furthermore, clinical evolution of CPM can be difficult to discern from the natural course of alcohol withdrawal delirium, requiring astuteness and maintenance of a high degree of clinical suspicion on the part of the physician. |
| format | Article |
| id | doaj-art-3cdd6944633c4f6ab9441a8f951929fb |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-3cdd6944633c4f6ab9441a8f951929fb2025-02-03T05:52:06ZengWileyCase Reports in Medicine1687-96271687-96352016-01-01201610.1155/2016/60652596065259Clinical Evolution of Central Pontine Myelinolysis in a Patient with Alcohol Withdrawal: A Blurred Clinical HorizonAbdul S. Mohammed0Prajwal Boddu1Dina F. Yazdani2Department of Internal Medicine, Advocate Illinois Masonic Medical Center, 2356 N. Elston Avenue, No. 306, Chicago, IL 60614, USADepartment of Internal Medicine, Advocate Illinois Masonic Medical Center, 856 W. Nelson Street, Apartment 2002, Chicago, IL 60657, USADeccan College of Medical Sciences, Kanchanbagh, Hyderabad, Telangana 500058, IndiaCentral pontine myelinolysis (CPM), a potentially fatal and debilitating neurological condition, was first described in 1959 in a study on alcoholic and malnourished patients. It is a condition most frequently related to rapid correction of hyponatremia. Chronic alcoholism associated CPM tends to be benign with a favorable prognosis compared to CPM secondary to rapid correction of hyponatremia. We describe a normonatremic, alcoholic patient who presented with CPM after a rapid rise in his sodium levels. Our case illustrates the fact that CPM can manifest even in patients who are normonatremic at baseline. Rapid rises in sodium levels should be promptly reversed before clinical symptoms manifest in patient with risk factors for CPM irrespective of their baseline sodium levels. Furthermore, clinical evolution of CPM can be difficult to discern from the natural course of alcohol withdrawal delirium, requiring astuteness and maintenance of a high degree of clinical suspicion on the part of the physician.http://dx.doi.org/10.1155/2016/6065259 |
| spellingShingle | Abdul S. Mohammed Prajwal Boddu Dina F. Yazdani Clinical Evolution of Central Pontine Myelinolysis in a Patient with Alcohol Withdrawal: A Blurred Clinical Horizon Case Reports in Medicine |
| title | Clinical Evolution of Central Pontine Myelinolysis in a Patient with Alcohol Withdrawal: A Blurred Clinical Horizon |
| title_full | Clinical Evolution of Central Pontine Myelinolysis in a Patient with Alcohol Withdrawal: A Blurred Clinical Horizon |
| title_fullStr | Clinical Evolution of Central Pontine Myelinolysis in a Patient with Alcohol Withdrawal: A Blurred Clinical Horizon |
| title_full_unstemmed | Clinical Evolution of Central Pontine Myelinolysis in a Patient with Alcohol Withdrawal: A Blurred Clinical Horizon |
| title_short | Clinical Evolution of Central Pontine Myelinolysis in a Patient with Alcohol Withdrawal: A Blurred Clinical Horizon |
| title_sort | clinical evolution of central pontine myelinolysis in a patient with alcohol withdrawal a blurred clinical horizon |
| url | http://dx.doi.org/10.1155/2016/6065259 |
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