In Vitro Cestocidal Activity of Thymol on Mesocestoides corti Tetrathyridia and Adult Worms
Nothing is known about the possible effect of thymol or other compounds of essential oils against the adult worms of cestodes. The aim of the present work was to determine in vitro cestodicidal activity of thymol against Mesocestoides corti adult worms. Moreover, the in vitro effect on tetrathyridia...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2014/268135 |
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| author | M. Maggiore M. C. Elissondo |
| author_facet | M. Maggiore M. C. Elissondo |
| author_sort | M. Maggiore |
| collection | DOAJ |
| description | Nothing is known about the possible effect of thymol or other compounds of essential oils against the adult worms of cestodes. The aim of the present work was to determine in vitro cestodicidal activity of thymol against Mesocestoides corti adult worms. Moreover, the in vitro effect on tetrathyridia was also demonstrated. Tetrathyridia exposed to different concentrations of thymol showed a concentration and time-dependent effect. At lower concentrations, the main change observed was mainly in morphology, with larvae exhibiting an elongation of the body. When tetrathyridia were exposed to higher concentrations, increased surface alterations and damage were detected. The body appeared elongated and flattened, and a complete loss of morphology and microtriches was observed. Thymol was able to kill M. corti tetrathyridia, since following inoculation of treated parasites in mice no parasites could be recovered. The effect on M. corti adult worms was dose and time-dependent. Changes in motility coincide with the tissue damage were observed at the structural and ultrastructural level. Thymol caused severe damages to both developmental stages analyzed. Damages were more significant in fully segmented worms. The data reported in this paper demonstrate a clear in vitro effect of thymol against M. corti tetrathyridia and adult worms. |
| format | Article |
| id | doaj-art-3cd9894fcf604991967340e20cf5686e |
| institution | Kabale University |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-3cd9894fcf604991967340e20cf5686e2025-02-03T01:07:51ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982014-01-01201410.1155/2014/268135268135In Vitro Cestocidal Activity of Thymol on Mesocestoides corti Tetrathyridia and Adult WormsM. Maggiore0M. C. Elissondo1Laboratorio de Zoonosis Parasitarias, Departamento de Biología, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata (UNMdP), 3350 Funes Street, 7600 Mar del Plata, ArgentinaLaboratorio de Zoonosis Parasitarias, Departamento de Biología, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata (UNMdP), 3350 Funes Street, 7600 Mar del Plata, ArgentinaNothing is known about the possible effect of thymol or other compounds of essential oils against the adult worms of cestodes. The aim of the present work was to determine in vitro cestodicidal activity of thymol against Mesocestoides corti adult worms. Moreover, the in vitro effect on tetrathyridia was also demonstrated. Tetrathyridia exposed to different concentrations of thymol showed a concentration and time-dependent effect. At lower concentrations, the main change observed was mainly in morphology, with larvae exhibiting an elongation of the body. When tetrathyridia were exposed to higher concentrations, increased surface alterations and damage were detected. The body appeared elongated and flattened, and a complete loss of morphology and microtriches was observed. Thymol was able to kill M. corti tetrathyridia, since following inoculation of treated parasites in mice no parasites could be recovered. The effect on M. corti adult worms was dose and time-dependent. Changes in motility coincide with the tissue damage were observed at the structural and ultrastructural level. Thymol caused severe damages to both developmental stages analyzed. Damages were more significant in fully segmented worms. The data reported in this paper demonstrate a clear in vitro effect of thymol against M. corti tetrathyridia and adult worms.http://dx.doi.org/10.1155/2014/268135 |
| spellingShingle | M. Maggiore M. C. Elissondo In Vitro Cestocidal Activity of Thymol on Mesocestoides corti Tetrathyridia and Adult Worms Interdisciplinary Perspectives on Infectious Diseases |
| title | In Vitro Cestocidal Activity of Thymol on Mesocestoides corti Tetrathyridia and Adult Worms |
| title_full | In Vitro Cestocidal Activity of Thymol on Mesocestoides corti Tetrathyridia and Adult Worms |
| title_fullStr | In Vitro Cestocidal Activity of Thymol on Mesocestoides corti Tetrathyridia and Adult Worms |
| title_full_unstemmed | In Vitro Cestocidal Activity of Thymol on Mesocestoides corti Tetrathyridia and Adult Worms |
| title_short | In Vitro Cestocidal Activity of Thymol on Mesocestoides corti Tetrathyridia and Adult Worms |
| title_sort | in vitro cestocidal activity of thymol on mesocestoides corti tetrathyridia and adult worms |
| url | http://dx.doi.org/10.1155/2014/268135 |
| work_keys_str_mv | AT mmaggiore invitrocestocidalactivityofthymolonmesocestoidescortitetrathyridiaandadultworms AT mcelissondo invitrocestocidalactivityofthymolonmesocestoidescortitetrathyridiaandadultworms |