Membrane Proteins Involved in Epithelial-Mesenchymal Transition and Tumor Invasion: Studies on TMPRSS4 and TM4SF5
The epithelial-mesenchymal transition (EMT) is one mechanism by which cells with mesenchymal features can be generated and is a fundamental event in morphogenesis. Recently, invasion and metastasis of cancer cells from the primary tumor are now thought to be initiated by the developmental process te...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BioMed Central
2014-03-01
|
| Series: | Genomics & Informatics |
| Subjects: | |
| Online Access: | http://genominfo.org/upload/pdf/gni-12-12.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832569182082826240 |
|---|---|
| author | Semi Kim Jung Weon Lee |
| author_facet | Semi Kim Jung Weon Lee |
| author_sort | Semi Kim |
| collection | DOAJ |
| description | The epithelial-mesenchymal transition (EMT) is one mechanism by which cells with mesenchymal features can be generated and is a fundamental event in morphogenesis. Recently, invasion and metastasis of cancer cells from the primary tumor are now thought to be initiated by the developmental process termed the EMT, whereby epithelial cells lose cell polarity and cell-cell interactions, and gain mesenchymal phenotypes with increased migratory and invasive properties. The EMT is believed to be an important step in metastasis and is implicated in cancer progression, although the influence of the EMT in clinical specimens has been debated. This review presents the recent results of two cell surface proteins, the functions and underlying mechanisms of which have recently begun to be demonstrated, as novel regulators of the molecular networks that induce the EMT and cancer progression. |
| format | Article |
| id | doaj-art-3cd0c90c90ee4cb9853b97820729f43e |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2014-03-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-3cd0c90c90ee4cb9853b97820729f43e2025-02-02T22:50:03ZengBioMed CentralGenomics & Informatics1598-866X2234-07422014-03-01121122010.5808/GI.2014.12.1.1295Membrane Proteins Involved in Epithelial-Mesenchymal Transition and Tumor Invasion: Studies on TMPRSS4 and TM4SF5Semi Kim0Jung Weon Lee1Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea.Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 151-742, Korea.The epithelial-mesenchymal transition (EMT) is one mechanism by which cells with mesenchymal features can be generated and is a fundamental event in morphogenesis. Recently, invasion and metastasis of cancer cells from the primary tumor are now thought to be initiated by the developmental process termed the EMT, whereby epithelial cells lose cell polarity and cell-cell interactions, and gain mesenchymal phenotypes with increased migratory and invasive properties. The EMT is believed to be an important step in metastasis and is implicated in cancer progression, although the influence of the EMT in clinical specimens has been debated. This review presents the recent results of two cell surface proteins, the functions and underlying mechanisms of which have recently begun to be demonstrated, as novel regulators of the molecular networks that induce the EMT and cancer progression.http://genominfo.org/upload/pdf/gni-12-12.pdfepithelial-mesenchymal transitioninvasionmembrane proteinsTM4SF5TMPRSS4 |
| spellingShingle | Semi Kim Jung Weon Lee Membrane Proteins Involved in Epithelial-Mesenchymal Transition and Tumor Invasion: Studies on TMPRSS4 and TM4SF5 Genomics & Informatics epithelial-mesenchymal transition invasion membrane proteins TM4SF5 TMPRSS4 |
| title | Membrane Proteins Involved in Epithelial-Mesenchymal Transition and Tumor Invasion: Studies on TMPRSS4 and TM4SF5 |
| title_full | Membrane Proteins Involved in Epithelial-Mesenchymal Transition and Tumor Invasion: Studies on TMPRSS4 and TM4SF5 |
| title_fullStr | Membrane Proteins Involved in Epithelial-Mesenchymal Transition and Tumor Invasion: Studies on TMPRSS4 and TM4SF5 |
| title_full_unstemmed | Membrane Proteins Involved in Epithelial-Mesenchymal Transition and Tumor Invasion: Studies on TMPRSS4 and TM4SF5 |
| title_short | Membrane Proteins Involved in Epithelial-Mesenchymal Transition and Tumor Invasion: Studies on TMPRSS4 and TM4SF5 |
| title_sort | membrane proteins involved in epithelial mesenchymal transition and tumor invasion studies on tmprss4 and tm4sf5 |
| topic | epithelial-mesenchymal transition invasion membrane proteins TM4SF5 TMPRSS4 |
| url | http://genominfo.org/upload/pdf/gni-12-12.pdf |
| work_keys_str_mv | AT semikim membraneproteinsinvolvedinepithelialmesenchymaltransitionandtumorinvasionstudiesontmprss4andtm4sf5 AT jungweonlee membraneproteinsinvolvedinepithelialmesenchymaltransitionandtumorinvasionstudiesontmprss4andtm4sf5 |