Antioxidant Vitamins in the Prevention of Atrial Fibrillation: What Is the Evidence?
Atrial fibrillation (AF) is the most common sustained arrhythmia that is associated with significant morbidity and mortality. Current available therapies remain inadequate in symptom control and secondary prevention and are often associated with significant side effects. The mechanisms underlying th...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.4061/2011/164078 |
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| author | Sonia Rasoli Nicholaos Kakouros Leanne Harling Philemon Gukop Manish Soni Thanos Athanasiou Antonios Kourliouros |
| author_facet | Sonia Rasoli Nicholaos Kakouros Leanne Harling Philemon Gukop Manish Soni Thanos Athanasiou Antonios Kourliouros |
| author_sort | Sonia Rasoli |
| collection | DOAJ |
| description | Atrial fibrillation (AF) is the most common sustained arrhythmia that is associated with significant morbidity and mortality. Current available therapies remain inadequate in symptom control and secondary prevention and are often associated with significant side effects. The mechanisms underlying the pathogenesis of AF are poorly understood, although electrophysiological remodeling has been described as an important initiating step. Recently, increasing evidence implicates oxidative stress and inflammation in the pathogenesis of AF. We searched the literature for evidence to support the use of antioxidant vitamins C and E in the prevention of AF. These vitamins, through their reactive-oxygen-species- (ROS-) scavenging effect, have shown a role in AF prevention in both animal and small clinical studies. The available evidence, however, is currently insufficient to support recommendations for their use in the wider patient population. Larger-scale clinical studies are required to confirm these preliminary results. Research is also required to further the understanding of the processes involved in the pathogenesis of AF and the role of antioxidant therapies to prevent the arrhythmia. |
| format | Article |
| id | doaj-art-3caa1d1cc751456a894361c2d35aa21e |
| institution | Kabale University |
| issn | 2090-0597 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-3caa1d1cc751456a894361c2d35aa21e2025-02-03T01:24:27ZengWileyCardiology Research and Practice2090-05972011-01-01201110.4061/2011/164078164078Antioxidant Vitamins in the Prevention of Atrial Fibrillation: What Is the Evidence?Sonia Rasoli0Nicholaos Kakouros1Leanne Harling2Philemon Gukop3Manish Soni4Thanos Athanasiou5Antonios Kourliouros6Department of Cardiothoracic Surgery, St George's Hospital, London SW17 0QT, UKDepartment of Cardiology, Johns Hopkins Hospital, Baltimore, MD 21209, USADepartment of Cardiothoracic Surgery, Imperial College Healthcare, London W12 0HS, UKDepartment of Cardiothoracic Surgery, St George's Hospital, London SW17 0QT, UKDepartment of Cardiothoracic Surgery, St George's Hospital, London SW17 0QT, UKDepartment of Cardiothoracic Surgery, Imperial College Healthcare, London W12 0HS, UKDepartment of Cardiac Surgery, St Thomas' Hospital, London SE1 7EH, UKAtrial fibrillation (AF) is the most common sustained arrhythmia that is associated with significant morbidity and mortality. Current available therapies remain inadequate in symptom control and secondary prevention and are often associated with significant side effects. The mechanisms underlying the pathogenesis of AF are poorly understood, although electrophysiological remodeling has been described as an important initiating step. Recently, increasing evidence implicates oxidative stress and inflammation in the pathogenesis of AF. We searched the literature for evidence to support the use of antioxidant vitamins C and E in the prevention of AF. These vitamins, through their reactive-oxygen-species- (ROS-) scavenging effect, have shown a role in AF prevention in both animal and small clinical studies. The available evidence, however, is currently insufficient to support recommendations for their use in the wider patient population. Larger-scale clinical studies are required to confirm these preliminary results. Research is also required to further the understanding of the processes involved in the pathogenesis of AF and the role of antioxidant therapies to prevent the arrhythmia.http://dx.doi.org/10.4061/2011/164078 |
| spellingShingle | Sonia Rasoli Nicholaos Kakouros Leanne Harling Philemon Gukop Manish Soni Thanos Athanasiou Antonios Kourliouros Antioxidant Vitamins in the Prevention of Atrial Fibrillation: What Is the Evidence? Cardiology Research and Practice |
| title | Antioxidant Vitamins in the Prevention of Atrial Fibrillation: What Is the Evidence? |
| title_full | Antioxidant Vitamins in the Prevention of Atrial Fibrillation: What Is the Evidence? |
| title_fullStr | Antioxidant Vitamins in the Prevention of Atrial Fibrillation: What Is the Evidence? |
| title_full_unstemmed | Antioxidant Vitamins in the Prevention of Atrial Fibrillation: What Is the Evidence? |
| title_short | Antioxidant Vitamins in the Prevention of Atrial Fibrillation: What Is the Evidence? |
| title_sort | antioxidant vitamins in the prevention of atrial fibrillation what is the evidence |
| url | http://dx.doi.org/10.4061/2011/164078 |
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