Combining local cytokine delivery and systemic immunization with recombinant artLCMV boosts antitumor efficacy in several preclinical tumor models

Combining local cytokine delivery and systemic immunization with recombinant artLCMV boosts antitumor efficacy in several preclinical tumor models

Among the plethora of cancer immune evasion mechanisms, T-cell-inhibiting factors within the tumor microenvironment impose a major challenge for the development of novel immunotherapies. Strategies to overcome immunosuppression and remodel the TME are therefore urgently needed. Therapeutic cancer va...

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Bibliographic Details
Main Authors: Kimberly Pojar, Diana Reckendorfer, Judith Strauss, Sarah Szaffich, Sarah Ahmadi-Erber, Timo Schippers, Pedro Berraondo, Klaus K. Orlinger, Josipa Raguz, Henning Lauterbach
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:OncoImmunology
Subjects:
Arenavirus vectors
artLCMV
cancer immunotherapy
cancer vaccine
IL-12
intratumoral virotherapy
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2025.2514040
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