Toll-Like Receptor 3 in Liver Diseases
Toll-like receptor 3 (TLR3) is a member of the TLR family that can recognize double-stranded RNA (dsRNA), playing an important role in antiviral immunity. Recent studies have shown that TLR3 is also expressed on parenchymal and nonparenchymal cells in the liver as well as on several types of immune...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2010/750904 |
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| _version_ | 1850105209192185856 |
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| author | Shi Yin Bin Gao |
| author_facet | Shi Yin Bin Gao |
| author_sort | Shi Yin |
| collection | DOAJ |
| description | Toll-like receptor 3 (TLR3) is a member of the TLR family that can recognize double-stranded RNA (dsRNA), playing an important role in antiviral immunity. Recent studies have shown that TLR3 is also expressed on parenchymal and nonparenchymal cells in the liver as well as on several types of immune cells. In this review, we summarize the role of TLR3 in liver injury, inflammation, regeneration, and liver fibrosis, and discuss the implication of TLR3 in the pathogenesis of human liver diseases including viral hepatitis and autoimmune liver disease. |
| format | Article |
| id | doaj-art-3ca8a7cfd6304ad9ac5eb1ef9c5e15c4 |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-3ca8a7cfd6304ad9ac5eb1ef9c5e15c42025-08-20T02:39:09ZengWileyGastroenterology Research and Practice1687-61211687-630X2010-01-01201010.1155/2010/750904750904Toll-Like Receptor 3 in Liver DiseasesShi Yin0Bin Gao1Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, 5625 Fishers Lane, MD 20892, USALaboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, 5625 Fishers Lane, MD 20892, USAToll-like receptor 3 (TLR3) is a member of the TLR family that can recognize double-stranded RNA (dsRNA), playing an important role in antiviral immunity. Recent studies have shown that TLR3 is also expressed on parenchymal and nonparenchymal cells in the liver as well as on several types of immune cells. In this review, we summarize the role of TLR3 in liver injury, inflammation, regeneration, and liver fibrosis, and discuss the implication of TLR3 in the pathogenesis of human liver diseases including viral hepatitis and autoimmune liver disease.http://dx.doi.org/10.1155/2010/750904 |
| spellingShingle | Shi Yin Bin Gao Toll-Like Receptor 3 in Liver Diseases Gastroenterology Research and Practice |
| title | Toll-Like Receptor 3 in Liver Diseases |
| title_full | Toll-Like Receptor 3 in Liver Diseases |
| title_fullStr | Toll-Like Receptor 3 in Liver Diseases |
| title_full_unstemmed | Toll-Like Receptor 3 in Liver Diseases |
| title_short | Toll-Like Receptor 3 in Liver Diseases |
| title_sort | toll like receptor 3 in liver diseases |
| url | http://dx.doi.org/10.1155/2010/750904 |
| work_keys_str_mv | AT shiyin tolllikereceptor3inliverdiseases AT bingao tolllikereceptor3inliverdiseases |