Global Patterns of Prostate Cancer Incidence, Aggressiveness, and Mortality in Men of African Descent
Prostate cancer (CaP) is the leading cancer among men of African descent in the USA, Caribbean, and Sub-Saharan Africa (SSA). The estimated number of CaP deaths in SSA during 2008 was more than five times that among African Americans and is expected to double in Africa by 2030. We summarize publicly...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2013/560857 |
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| author | Timothy R. Rebbeck Susan S. Devesa Bao-Li Chang Clareann H. Bunker Iona Cheng Kathleen Cooney Rosalind Eeles Pedro Fernandez Veda N. Giri Serigne M. Gueye Christopher A. Haiman Brian E. Henderson Chris F. Heyns Jennifer J. Hu Sue Ann Ingles William Isaacs Mohamed Jalloh Esther M. John Adam S. Kibel LaCreis R. Kidd Penelope Layne Robin J. Leach Christine Neslund-Dudas Michael N. Okobia Elaine A. Ostrander Jong Y. Park Alan L. Patrick Catherine M. Phelan Camille Ragin Robin A. Roberts Benjamin A. Rybicki Janet L. Stanford Sara Strom Ian M. Thompson John Witte Jianfeng Xu Edward Yeboah Ann W. Hsing Charnita M. Zeigler-Johnson |
| author_facet | Timothy R. Rebbeck Susan S. Devesa Bao-Li Chang Clareann H. Bunker Iona Cheng Kathleen Cooney Rosalind Eeles Pedro Fernandez Veda N. Giri Serigne M. Gueye Christopher A. Haiman Brian E. Henderson Chris F. Heyns Jennifer J. Hu Sue Ann Ingles William Isaacs Mohamed Jalloh Esther M. John Adam S. Kibel LaCreis R. Kidd Penelope Layne Robin J. Leach Christine Neslund-Dudas Michael N. Okobia Elaine A. Ostrander Jong Y. Park Alan L. Patrick Catherine M. Phelan Camille Ragin Robin A. Roberts Benjamin A. Rybicki Janet L. Stanford Sara Strom Ian M. Thompson John Witte Jianfeng Xu Edward Yeboah Ann W. Hsing Charnita M. Zeigler-Johnson |
| author_sort | Timothy R. Rebbeck |
| collection | DOAJ |
| description | Prostate cancer (CaP) is the leading cancer among men of African descent in the USA, Caribbean, and Sub-Saharan Africa (SSA). The estimated number of CaP deaths in SSA during 2008 was more than five times that among African Americans and is expected to double in Africa by 2030. We summarize publicly available CaP data and collected data from the men of African descent and Carcinoma of the Prostate (MADCaP) Consortium and the African Caribbean Cancer Consortium (AC3) to evaluate CaP incidence and mortality in men of African descent worldwide. CaP incidence and mortality are highest in men of African descent in the USA and the Caribbean. Tumor stage and grade were highest in SSA. We report a higher proportion of T1 stage prostate tumors in countries with greater percent gross domestic product spent on health care and physicians per 100,000 persons. We also observed that regions with a higher proportion of advanced tumors reported lower mortality rates. This finding suggests that CaP is underdiagnosed and/or underreported in SSA men. Nonetheless, CaP incidence and mortality represent a significant public health problem in men of African descent around the world. |
| format | Article |
| id | doaj-art-3c911fecc8ae4dc4bb5ee472506592b7 |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-3c911fecc8ae4dc4bb5ee472506592b72025-02-03T05:44:01ZengWileyProstate Cancer2090-31112090-312X2013-01-01201310.1155/2013/560857560857Global Patterns of Prostate Cancer Incidence, Aggressiveness, and Mortality in Men of African DescentTimothy R. Rebbeck0Susan S. Devesa1Bao-Li Chang2Clareann H. Bunker3Iona Cheng4Kathleen Cooney5Rosalind Eeles6Pedro Fernandez7Veda N. Giri8Serigne M. Gueye9Christopher A. Haiman10Brian E. Henderson11Chris F. Heyns12Jennifer J. Hu13Sue Ann Ingles14William Isaacs15Mohamed Jalloh16Esther M. John17Adam S. Kibel18LaCreis R. Kidd19Penelope Layne20Robin J. Leach21Christine Neslund-Dudas22Michael N. Okobia23Elaine A. Ostrander24Jong Y. Park25Alan L. Patrick26Catherine M. Phelan27Camille Ragin28Robin A. Roberts29Benjamin A. Rybicki30Janet L. Stanford31Sara Strom32Ian M. Thompson33John Witte34Jianfeng Xu35Edward Yeboah36Ann W. Hsing37Charnita M. Zeigler-Johnson38Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 217 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USADivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USADepartment of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 217 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USADepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15213, USACancer Prevention Institute of California, Fremont, CA 94538, USADepartment of Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USAThe Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UKStellenbosch University and Tygerberg Hospital, Cape Town 7505, South AfricaFox Chase Cancer Center, Philadelphia, PA 19111, USAHôpital Général de Grand Yoff, Université Cheikh Anta Diop de Dakar, Dakar, SenegalDepartment of Preventive Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USADepartment of Preventive Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USAStellenbosch University and Tygerberg Hospital, Cape Town 7505, South AfricaSchool of Medicine and Sylvester Cancer Center, University of Miami Miller, Miami, FL 33442, USADepartment of Preventive Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USAThe Johns Hopkins University School of Medicine and Bloomberg School of Public Health, Baltimore, MD 21287, USAHôpital Général de Grand Yoff, Université Cheikh Anta Diop de Dakar, Dakar, SenegalCancer Prevention Institute of California, Fremont, CA 94538, USADepartment of Surgery, Brigham and Women’s Hospital, Boston, MA 02138, USADepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, USAGuyana Cancer Registry, Ministry of Health, Queenstown, GuyanaDepartment of Urology and the Cancer, Therapy and Research Center, The University of Texas Health Science Center at San Antonio, San Antonio, San Antonio, TX 78229, USADepartment of Public Health Sciences, Henry Ford Hospital, Detroit, MI 48202, USADepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15213, USANational Human Genome Research Institute, Bethesda, MD 20892, USADepartment of Cancer Epidemiology and Center for Equal Health, Moffitt Cancer Center, Tampa, FL 33612, USATobago Health Studies Office, Scarborough, Tobago, Trinidad and TobagoDepartment of Cancer Epidemiology and Center for Equal Health, Moffitt Cancer Center, Tampa, FL 33612, USAFox Chase Cancer Center, Philadelphia, PA 19111, USASchool of Clinical Medicine and Research, University of the West Indies, Nassau, BahamasDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, MI 48202, USAFred Hutchinson Cancer Research Center, Seattle, WA 98109, USADepartment of Epidemiology, MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Urology and the Cancer, Therapy and Research Center, The University of Texas Health Science Center at San Antonio, San Antonio, San Antonio, TX 78229, USADepartments of Epidemiology and Biostatistics and Urology, Institute for Human Genetics, University of California, San Francisco, CA 94122, USAWake Forest University, Winston-Salem, NC 27157, USAKorle Bu Teaching Hospital and University of Ghana Medical School, Accra, GhanaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USADepartment of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 217 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USAProstate cancer (CaP) is the leading cancer among men of African descent in the USA, Caribbean, and Sub-Saharan Africa (SSA). The estimated number of CaP deaths in SSA during 2008 was more than five times that among African Americans and is expected to double in Africa by 2030. We summarize publicly available CaP data and collected data from the men of African descent and Carcinoma of the Prostate (MADCaP) Consortium and the African Caribbean Cancer Consortium (AC3) to evaluate CaP incidence and mortality in men of African descent worldwide. CaP incidence and mortality are highest in men of African descent in the USA and the Caribbean. Tumor stage and grade were highest in SSA. We report a higher proportion of T1 stage prostate tumors in countries with greater percent gross domestic product spent on health care and physicians per 100,000 persons. We also observed that regions with a higher proportion of advanced tumors reported lower mortality rates. This finding suggests that CaP is underdiagnosed and/or underreported in SSA men. Nonetheless, CaP incidence and mortality represent a significant public health problem in men of African descent around the world.http://dx.doi.org/10.1155/2013/560857 |
| spellingShingle | Timothy R. Rebbeck Susan S. Devesa Bao-Li Chang Clareann H. Bunker Iona Cheng Kathleen Cooney Rosalind Eeles Pedro Fernandez Veda N. Giri Serigne M. Gueye Christopher A. Haiman Brian E. Henderson Chris F. Heyns Jennifer J. Hu Sue Ann Ingles William Isaacs Mohamed Jalloh Esther M. John Adam S. Kibel LaCreis R. Kidd Penelope Layne Robin J. Leach Christine Neslund-Dudas Michael N. Okobia Elaine A. Ostrander Jong Y. Park Alan L. Patrick Catherine M. Phelan Camille Ragin Robin A. Roberts Benjamin A. Rybicki Janet L. Stanford Sara Strom Ian M. Thompson John Witte Jianfeng Xu Edward Yeboah Ann W. Hsing Charnita M. Zeigler-Johnson Global Patterns of Prostate Cancer Incidence, Aggressiveness, and Mortality in Men of African Descent Prostate Cancer |
| title | Global Patterns of Prostate Cancer Incidence, Aggressiveness, and Mortality in Men of African Descent |
| title_full | Global Patterns of Prostate Cancer Incidence, Aggressiveness, and Mortality in Men of African Descent |
| title_fullStr | Global Patterns of Prostate Cancer Incidence, Aggressiveness, and Mortality in Men of African Descent |
| title_full_unstemmed | Global Patterns of Prostate Cancer Incidence, Aggressiveness, and Mortality in Men of African Descent |
| title_short | Global Patterns of Prostate Cancer Incidence, Aggressiveness, and Mortality in Men of African Descent |
| title_sort | global patterns of prostate cancer incidence aggressiveness and mortality in men of african descent |
| url | http://dx.doi.org/10.1155/2013/560857 |
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