EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration

Unraveling the molecular clues of liver proliferation has become conceivable thanks to the model of two-third hepatectomy. The synchronicity and the well-scheduled aspect of this process allow scientists to slowly decipher this mystery. During this phenomenon, quiescent hepatocytes of the remnant lo...

Full description

Saved in:
Bibliographic Details
Main Authors: Alexandra Collin de l'Hortet, Hélène Gilgenkrantz, Jacques-Emmanuel Guidotti
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:International Journal of Hepatology
Online Access:http://dx.doi.org/10.1155/2012/476910
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832551940658036736
author Alexandra Collin de l'Hortet
Hélène Gilgenkrantz
Jacques-Emmanuel Guidotti
author_facet Alexandra Collin de l'Hortet
Hélène Gilgenkrantz
Jacques-Emmanuel Guidotti
author_sort Alexandra Collin de l'Hortet
collection DOAJ
description Unraveling the molecular clues of liver proliferation has become conceivable thanks to the model of two-third hepatectomy. The synchronicity and the well-scheduled aspect of this process allow scientists to slowly decipher this mystery. During this phenomenon, quiescent hepatocytes of the remnant lobes are able to reenter into the cell cycle initiating the G1-S progression synchronously before completing the cell cycle. The major role played by this step of the cell cycle has been emphasized by loss-of-function studies showing a delay or a lack of coordination in the hepatocytes G1-S progression. Two growth factor receptors, c-Met and EGFR, tightly drive this transition. Due to the level of complexity surrounding EGFR signaling, involving numerous ligands, highly controlled regulations and multiple downstream pathways, we chose to focus on the EGFR pathway for this paper. We will first describe the EGFR pathway in its integrity and then address its essential role in the G1/S phase transition for hepatocyte proliferation. Recently, other levels of control have been discovered to monitor this pathway, which will lead us to discuss regulations of the EGFR pathway and highlight the potential effect of misregulations in pathologies.
format Article
id doaj-art-3c905091211d4d41a9caa88d3282d86e
institution Kabale University
issn 2090-3448
2090-3456
language English
publishDate 2012-01-01
publisher Wiley
record_format Article
series International Journal of Hepatology
spelling doaj-art-3c905091211d4d41a9caa88d3282d86e2025-02-03T05:59:55ZengWileyInternational Journal of Hepatology2090-34482090-34562012-01-01201210.1155/2012/476910476910EGFR: A Master Piece in G1/S Phase Transition of Liver RegenerationAlexandra Collin de l'Hortet0Hélène Gilgenkrantz1Jacques-Emmanuel Guidotti2Institut Cochin, Department of Endocrinology Metabolism and Cancer, Université Paris-Descartes, CNRS, UMR8104, 75014 Paris, FranceInstitut Cochin, Department of Endocrinology Metabolism and Cancer, Université Paris-Descartes, CNRS, UMR8104, 75014 Paris, FranceInstitut Cochin, Department of Endocrinology Metabolism and Cancer, Université Paris-Descartes, CNRS, UMR8104, 75014 Paris, FranceUnraveling the molecular clues of liver proliferation has become conceivable thanks to the model of two-third hepatectomy. The synchronicity and the well-scheduled aspect of this process allow scientists to slowly decipher this mystery. During this phenomenon, quiescent hepatocytes of the remnant lobes are able to reenter into the cell cycle initiating the G1-S progression synchronously before completing the cell cycle. The major role played by this step of the cell cycle has been emphasized by loss-of-function studies showing a delay or a lack of coordination in the hepatocytes G1-S progression. Two growth factor receptors, c-Met and EGFR, tightly drive this transition. Due to the level of complexity surrounding EGFR signaling, involving numerous ligands, highly controlled regulations and multiple downstream pathways, we chose to focus on the EGFR pathway for this paper. We will first describe the EGFR pathway in its integrity and then address its essential role in the G1/S phase transition for hepatocyte proliferation. Recently, other levels of control have been discovered to monitor this pathway, which will lead us to discuss regulations of the EGFR pathway and highlight the potential effect of misregulations in pathologies.http://dx.doi.org/10.1155/2012/476910
spellingShingle Alexandra Collin de l'Hortet
Hélène Gilgenkrantz
Jacques-Emmanuel Guidotti
EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration
International Journal of Hepatology
title EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration
title_full EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration
title_fullStr EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration
title_full_unstemmed EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration
title_short EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration
title_sort egfr a master piece in g1 s phase transition of liver regeneration
url http://dx.doi.org/10.1155/2012/476910
work_keys_str_mv AT alexandracollindelhortet egframasterpieceing1sphasetransitionofliverregeneration
AT helenegilgenkrantz egframasterpieceing1sphasetransitionofliverregeneration
AT jacquesemmanuelguidotti egframasterpieceing1sphasetransitionofliverregeneration