EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration
Unraveling the molecular clues of liver proliferation has become conceivable thanks to the model of two-third hepatectomy. The synchronicity and the well-scheduled aspect of this process allow scientists to slowly decipher this mystery. During this phenomenon, quiescent hepatocytes of the remnant lo...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2012/476910 |
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| author | Alexandra Collin de l'Hortet Hélène Gilgenkrantz Jacques-Emmanuel Guidotti |
| author_facet | Alexandra Collin de l'Hortet Hélène Gilgenkrantz Jacques-Emmanuel Guidotti |
| author_sort | Alexandra Collin de l'Hortet |
| collection | DOAJ |
| description | Unraveling the molecular clues of liver proliferation has become conceivable thanks to the model of two-third hepatectomy. The synchronicity and the well-scheduled aspect of this process allow scientists to slowly decipher this mystery. During this phenomenon, quiescent hepatocytes of the remnant lobes are able to reenter into the cell cycle initiating the G1-S progression synchronously before completing the cell cycle. The major role played by this step of the cell cycle has been emphasized by loss-of-function studies showing a delay or a lack of coordination in the hepatocytes G1-S progression. Two growth factor receptors, c-Met and EGFR, tightly drive this transition. Due to the level of complexity surrounding EGFR signaling, involving numerous ligands, highly controlled regulations and multiple downstream pathways, we chose to focus on the EGFR pathway for this paper. We will first describe the EGFR pathway in its integrity and then address its essential role in the G1/S phase transition for hepatocyte proliferation. Recently, other levels of control have been discovered to monitor this pathway, which will lead us to discuss regulations of the EGFR pathway and highlight the potential effect of misregulations in pathologies. |
| format | Article |
| id | doaj-art-3c905091211d4d41a9caa88d3282d86e |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-3c905091211d4d41a9caa88d3282d86e2025-02-03T05:59:55ZengWileyInternational Journal of Hepatology2090-34482090-34562012-01-01201210.1155/2012/476910476910EGFR: A Master Piece in G1/S Phase Transition of Liver RegenerationAlexandra Collin de l'Hortet0Hélène Gilgenkrantz1Jacques-Emmanuel Guidotti2Institut Cochin, Department of Endocrinology Metabolism and Cancer, Université Paris-Descartes, CNRS, UMR8104, 75014 Paris, FranceInstitut Cochin, Department of Endocrinology Metabolism and Cancer, Université Paris-Descartes, CNRS, UMR8104, 75014 Paris, FranceInstitut Cochin, Department of Endocrinology Metabolism and Cancer, Université Paris-Descartes, CNRS, UMR8104, 75014 Paris, FranceUnraveling the molecular clues of liver proliferation has become conceivable thanks to the model of two-third hepatectomy. The synchronicity and the well-scheduled aspect of this process allow scientists to slowly decipher this mystery. During this phenomenon, quiescent hepatocytes of the remnant lobes are able to reenter into the cell cycle initiating the G1-S progression synchronously before completing the cell cycle. The major role played by this step of the cell cycle has been emphasized by loss-of-function studies showing a delay or a lack of coordination in the hepatocytes G1-S progression. Two growth factor receptors, c-Met and EGFR, tightly drive this transition. Due to the level of complexity surrounding EGFR signaling, involving numerous ligands, highly controlled regulations and multiple downstream pathways, we chose to focus on the EGFR pathway for this paper. We will first describe the EGFR pathway in its integrity and then address its essential role in the G1/S phase transition for hepatocyte proliferation. Recently, other levels of control have been discovered to monitor this pathway, which will lead us to discuss regulations of the EGFR pathway and highlight the potential effect of misregulations in pathologies.http://dx.doi.org/10.1155/2012/476910 |
| spellingShingle | Alexandra Collin de l'Hortet Hélène Gilgenkrantz Jacques-Emmanuel Guidotti EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration International Journal of Hepatology |
| title | EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration |
| title_full | EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration |
| title_fullStr | EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration |
| title_full_unstemmed | EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration |
| title_short | EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration |
| title_sort | egfr a master piece in g1 s phase transition of liver regeneration |
| url | http://dx.doi.org/10.1155/2012/476910 |
| work_keys_str_mv | AT alexandracollindelhortet egframasterpieceing1sphasetransitionofliverregeneration AT helenegilgenkrantz egframasterpieceing1sphasetransitionofliverregeneration AT jacquesemmanuelguidotti egframasterpieceing1sphasetransitionofliverregeneration |