Ultrasonicated Synthesis of N-Benzyl-2,3-substituted Morpholines, via the Mitsunobu Diol Cyclisation

Ultrasonicated Synthesis of N-Benzyl-2,3-substituted Morpholines, via the Mitsunobu Diol Cyclisation

A facile five step synthesis of N-benzyl-2,3-substituted morpholines (i-iii) was performed. The key steps were microwave assisted Friedel-crafts acylation and diol cyclization carried out via an ultra sonication of Mitsunobu reaction using DEAD (diethylazodicarboxylate), TPP in THF for 1 h. The morp...

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Bibliographic Details
Main Authors:	B. Jayachandra Reddy, M. C. Somasekhara Reddy
Format:	Article
Language:	English
Published:	Wiley 2010-01-01
Series:	E-Journal of Chemistry
Online Access:	http://dx.doi.org/10.1155/2010/931015
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