Modeling of Scale-Dependent Bacterial Growth by Chemical Kinetics Approach
We applied the so-called chemical kinetics approach to complex bacterial growth patterns that were dependent on the liquid-surface-area-to-volume ratio (SA/V) of the bacterial cultures. The kinetic modeling was based on current experimental knowledge in terms of autocatalytic bacterial growth, its i...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/820959 |
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| author | Haydee Martínez Joaquín Sánchez José-Manuel Cruz Guadalupe Ayala Marco Rivera Thomas Buhse |
| author_facet | Haydee Martínez Joaquín Sánchez José-Manuel Cruz Guadalupe Ayala Marco Rivera Thomas Buhse |
| author_sort | Haydee Martínez |
| collection | DOAJ |
| description | We applied the so-called chemical kinetics approach to complex bacterial growth patterns that were dependent on the liquid-surface-area-to-volume ratio (SA/V) of the bacterial cultures. The kinetic modeling was based on current experimental knowledge in terms of autocatalytic bacterial growth, its inhibition by the metabolite CO2, and the relief of inhibition through the physical escape of the inhibitor. The model quantitatively reproduces kinetic data of SA/V-dependent bacterial growth and can discriminate between differences in the growth dynamics of enteropathogenic E. coli, E. coli JM83, and Salmonella typhimurium on one hand and Vibrio cholerae on the other hand. Furthermore, the data fitting procedures allowed predictions about the velocities of the involved key processes and the potential behavior in an open-flow bacterial chemostat, revealing an oscillatory approach to the stationary states. |
| format | Article |
| id | doaj-art-3c72b96697814ff0af21751c9fad90c5 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-3c72b96697814ff0af21751c9fad90c52025-02-03T01:28:51ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/820959820959Modeling of Scale-Dependent Bacterial Growth by Chemical Kinetics ApproachHaydee Martínez0Joaquín Sánchez1José-Manuel Cruz2Guadalupe Ayala3Marco Rivera4Thomas Buhse5Facultad de Medicina, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, 62209 Cuernavaca, MOR, MexicoFacultad de Medicina, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, 62209 Cuernavaca, MOR, MexicoCentro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, 62209 Cuernavaca, MOR, MexicoCentro de Investigación sobre Enfermedades Infecciosas, INSP, 62100 Cuernavaca, MOR, MexicoFacultad de Ciencias, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, 62209 Cuernavaca, MOR, MexicoCentro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, 62209 Cuernavaca, MOR, MexicoWe applied the so-called chemical kinetics approach to complex bacterial growth patterns that were dependent on the liquid-surface-area-to-volume ratio (SA/V) of the bacterial cultures. The kinetic modeling was based on current experimental knowledge in terms of autocatalytic bacterial growth, its inhibition by the metabolite CO2, and the relief of inhibition through the physical escape of the inhibitor. The model quantitatively reproduces kinetic data of SA/V-dependent bacterial growth and can discriminate between differences in the growth dynamics of enteropathogenic E. coli, E. coli JM83, and Salmonella typhimurium on one hand and Vibrio cholerae on the other hand. Furthermore, the data fitting procedures allowed predictions about the velocities of the involved key processes and the potential behavior in an open-flow bacterial chemostat, revealing an oscillatory approach to the stationary states.http://dx.doi.org/10.1155/2014/820959 |
| spellingShingle | Haydee Martínez Joaquín Sánchez José-Manuel Cruz Guadalupe Ayala Marco Rivera Thomas Buhse Modeling of Scale-Dependent Bacterial Growth by Chemical Kinetics Approach The Scientific World Journal |
| title | Modeling of Scale-Dependent Bacterial Growth by Chemical Kinetics Approach |
| title_full | Modeling of Scale-Dependent Bacterial Growth by Chemical Kinetics Approach |
| title_fullStr | Modeling of Scale-Dependent Bacterial Growth by Chemical Kinetics Approach |
| title_full_unstemmed | Modeling of Scale-Dependent Bacterial Growth by Chemical Kinetics Approach |
| title_short | Modeling of Scale-Dependent Bacterial Growth by Chemical Kinetics Approach |
| title_sort | modeling of scale dependent bacterial growth by chemical kinetics approach |
| url | http://dx.doi.org/10.1155/2014/820959 |
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